Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor

J Lan, J Ge, J Yu, S Shan, H Zhou, S Fan, Q Zhang… - nature, 2020 - nature.com
… nationwide and to other countries around the world 1,2,3 . Here, to better understand the …
receptor-binding domain (RBD) of the spike protein of SARS-CoV-2 bound to the cell receptor

[PDF][PDF] The antigenic anatomy of SARS-CoV-2 receptor binding domain

W Dejnirattisai, D Zhou, HM Ginn, HME Duyvesteyn… - Cell, 2021 - cell.com
… Antibodies are crucial to immune protection against SARS-CoV-2, with some in emergency
… ) recognizing the virus spike and focus mainly on 80 that bind the receptor binding domain (…

Anti-SARS-CoV-2 receptor-binding domain antibody evolution after mRNA vaccination

A Cho, F Muecksch, D Schaefer-Babajew, Z Wang… - Nature, 2021 - nature.com
… Plasma binding and neutralization assays Plasma IgM, IgG and IgA responses to SARS-CoV-2
receptor-binding domain … As previously reported by others 2,4,5,6 , there was a significant …

Comparing the binding interactions in the receptor binding domains of SARS-CoV-2 and SARS-CoV

M Amin, MK Sorour, A Kasry - The journal of physical chemistry …, 2020 - ACS Publications
… -CoV-2 to the ACE2. Our results show that the protein surface of the ACE2 at the receptor
binding domain (RBD… is observed for the S proteins of SARS-CoV/SARS-CoV-2. In addition, the …

[HTML][HTML] Structural basis of receptor recognition by SARS-CoV-2

J Shang, G Ye, K Shi, Y Wan, C Luo, H Aihara, Q Geng… - Nature, 2020 - nature.com
receptor-binding domain (RBD) of the spike protein of SARS-… ACE2-binding affinity among
SARS-CoV-2, SARS-CoV and … of the SARS-CoV-2 RBM that result in tight ACE2 binding. …

The receptor-binding domain of the viral spike protein is an immunodominant and highly specific target of antibodies in SARS-CoV-2 patients

L Premkumar, B Segovia-Chumbez, R Jadi… - Science …, 2020 - science.org
… by SARS-CoVs. We observed a strong correlation between levels of RBD-binding antibodies
and SARS-CoV-2 … Our results, which reveal the early kinetics of SARS-CoV-2 antibody …

[HTML][HTML] Recognition of the SARS-CoV-2 receptor binding domain by neutralizing antibodies

M Yuan, H Liu, NC Wu, IA Wilson - Biochemical and biophysical research …, 2021 - Elsevier
SARS-CoV, SARS-CoV-2 binds to the host receptor, angiotensin-converting enzyme 2 (ACE2),
through the receptor binding domain (… virus, with its S1 head domain perched atop the S2

Shifting mutational constraints in the SARS-CoV-2 receptor-binding domain during viral evolution

TN Starr, AJ Greaney, WW Hannon, AN Loes, K Hauser… - Science, 2022 - science.org
… of ongoing SARS-CoV-2 evolution. The severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) spike receptor-binding domain (RBD) has evolved rapidly since the virus

[PDF][PDF] Comprehensive mapping of mutations in the SARS-CoV-2 receptor-binding domain that affect recognition by polyclonal human plasma antibodies

AJ Greaney, AN Loes, KHD Crawford, TN Starr… - Cell host & …, 2021 - cell.com
… to the spike’s receptor-binding domain (RBD) or N-terminal domain (NTD) can appreciably
… -acid mutations to the SARS-CoV-2 spike RBD affect binding by the antibodies in plasma …

Structure of SARS coronavirus spike receptor-binding domain complexed with receptor

F Li, W Li, M Farzan, SC Harrison - Science, 2005 - science.org
… use in the design of coronavirus vaccines. The SARS coronavirus (SARS-CoV) is the agent
of … a related protease into S1 and S2; the former bears the receptor attachment site; the latter, …