[HTML][HTML] Role of changes in SARS-CoV-2 spike protein in the interaction with the human ACE2 receptor: An in silico analysis

JT Ortega, ML Serrano, FH Pujol, HR Rangel - EXCLI journal, 2020 - ncbi.nlm.nih.gov
… , compared to the one of the Bat-CoV to this receptor. The data presented in … SARS-Cov-2
spike protein to the human ACE2 receptor, compared to the one of Bat-CoV spike and ACE2. …

[HTML][HTML] Dynamics of the ACE2SARS-CoV-2/SARS-CoV spike protein interface reveal unique mechanisms

A Ali, R Vijayan - Scientific reports, 2020 - nature.com
… the interaction between SARS-CoV/SARS-CoV-2 and ACE2. … the interactions between
SARS-CoV-2/SARS-CoV and ACE2interactions that define the ACE2SARS-CoV-2 and ACE2–…

Differential interactions between human ACE2 and spike RBD of SARS-CoV-2 variants of concern

S Kim, Y Liu, Z Lei, J Dicker, Y Cao… - Journal of chemical …, 2021 - ACS Publications
… ) variant is relatively easily detached from ACE2. Our results from both SMD simulations …
ACE2 interactions. This study could shed light on developing new drugs to inhibit SARS-CoV-2

Structural variations in human ACE2 may influence its binding with SARSCoV2 spike protein

M Hussain, N Jabeen, F Raza, S Shabbir… - Journal of medical …, 2020 - Wiley Online Library
… and molecular superimposition revealed important variations in the intermolecular interaction
between ACE2 alleles and SARS-CoV-2 spike protein. It is interesting to note that for two …

In silico studies on the comparative characterization of the interactions of SARSCoV2 spike glycoprotein with ACE2 receptor homologs and human TLRs

A Choudhury, S Mukherjee - Journal of medical virology, 2020 - Wiley Online Library
… of the spike protein of SARS-CoV-2 with the ACE2 receptor … interactions between spike protein
and its receptor (ACE2) from … spike protein-bat ACE2 > spike protein-human ACE2 > spike

[HTML][HTML] A cross-reactive human IgA monoclonal antibody blocks SARS-CoV-2 spike-ACE2 interaction

M Ejemel, Q Li, S Hou, ZA Schiller, JA Tree… - Nature …, 2020 - nature.com
… Interestingly, our results show that despite the same blocking of spike interaction with
ACE2, MAb362 IgG weakly neutralizes SARS-CoV-2, whereas IgA as monomer, dimer, or …

[HTML][HTML] Virus-receptor interactions of glycosylated SARS-CoV-2 spike and human ACE2 receptor

P Zhao, JL Praissman, OC Grant, Y Cai, T Xiao… - Cell host & …, 2020 - cell.com
… polypeptide epitopes and directly modulating Spike-ACE2 interactions. Furthermore, our …
on Spike glycosylation, as well as the influence of natural variants on ACE2 receptor …

[HTML][HTML] Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor

J Lan, J Ge, J Yu, S Shan, H Zhou, S Fan, Q Zhang… - nature, 2020 - nature.com
… the interaction between the SARS-CoV-2 RBD and ACE2 at … that the SARS-CoV-2 RBD–ACE2
and SARS-CoV RBD–ACE2 … of interacting residues and hydrophilic interaction networks, …

Engineering human ACE2 to optimize binding to the spike protein of SARS coronavirus 2

KK Chan, D Dorosky, P Sharma, SA Abbasi, JM Dye… - Science, 2020 - science.org
… , mutations in ACE2 that increase S binding are found across the interaction surface, in the
… for understanding the specificity of the interaction between ACE2 and S and for engineering …

Inhibition of ACE2Spike Interaction by an ACE2 Binder Suppresses SARSCoV2 Entry

YH Shin, K Jeong, J Lee, HJ Lee, J Yim… - Angewandte …, 2022 - Wiley Online Library
… ongoing COVID-19 pandemic. Here, we have identified a novel small molecule that inhibited
the interactions between SARS-CoV-2 spike RBDs and ACE2 by modulating ACE2 without …