Superantigenic character of an insert unique to SARS-CoV-2 spike supported by skewed TCR repertoire in patients with hyperinflammation

MH Cheng, S Zhang, RA Porritt… - Proceedings of the …, 2020 - National Acad Sciences
… We show that SARS-CoV-2 spike contains sequence and … We further report a skewed T
cell receptor repertoire in COVID-19 … is not present in other SARS family coronaviruses, which …

[HTML][HTML] SARS-CoV-2 epitopes are recognized by a public and diverse repertoire of human T cell receptors

AS Shomuradova, MS Vagida, SA Sheetikov… - Immunity, 2020 - cell.com
… to SARS-CoV-2 epitopes, revealing T cell receptor (TCR) motifs … spike protein were mediated
by groups of homologous TCRs, … to SARS-CoV-2, including the identified set of TCRs, can …

SARS-CoV-2 vaccination diversifies the CD4+ spike-reactive T cell repertoire in patients with prior SARS-CoV-2 infection

AG Dykema, B Zhang, BA Woldemeskel, CC Garliss… - …, 2022 - thelancet.com
… This study not only confirms the lifespan of SARS-CoV-2 TCR clonotypes but proves that
vaccination can maintain the overall number of clones through induction of new clones, thereby …

[HTML][HTML] Longitudinal analysis of T cell receptor repertoires reveals shared patterns of antigen-specific response to SARS-CoV-2 infection

RM Gittelman, E Lavezzo, TM Snyder, HJ Zahid… - JCI insight, 2022 - ncbi.nlm.nih.gov
SARS-CoV-2 spike protein (40), while the serology tests compared in this study target either
spike (LIAISON SARS-CoV-2 S1/S2 IgG, DiaSorin Molecular) or nucleoprotein (Elecsys Anti-…

SARS-CoV-2 antigen exposure history shapes phenotypes and specificity of memory CD8+ T cells

AA Minervina, MV Pogorelyy, AM Kirk, JC Crawford… - Nature …, 2022 - nature.com
… Selected spike and non-spike SARS-CoV-2 T cell epitopes … recruited TCR repertoires,
potentially narrowing repertoire … T cell memory repertoire established by SARS-CoV-2 infection or …

Establishment and recall of SARS-CoV-2 spike epitope-specific CD4+ T cell memory

KM Wragg, WS Lee, M Koutsakos, HX Tan… - Nature …, 2022 - nature.com
TCR repertoire of vaccine-induced TET 751 + T cells Analysis of SARS-CoV-2-specific TCR
repertoires … of hCoV cross-reactive TCR clonotypes present in uninfected individuals 37,38 . …

Structural assessment of HLA-A2-restricted SARS-CoV-2 spike epitopes recognized by public and private T-cell receptors

D Wu, A Kolesnikov, R Yin, JD Guest… - Nature …, 2022 - nature.com
… In most T cell responses, the TCR repertoires elicited by a particular antigenic epitope are
… By contrast, certain other epitope-specific TCR repertoires contain TCRs that are frequently …

The spike-specific TCRβ repertoire shows distinct features in unvaccinated or vaccinated patients with SARS-CoV-2 infection

E Vecchio, S Rotundo, C Veneziano, A Abatino… - Journal of Translational …, 2024 - Springer
… the capability of T-cell receptor (TCR) repertoire analysis to identify … TCR repertoire to
different clinical scenarios. The aim of this study was to examine the Spike-specific TCR repertoire

[HTML][HTML] The pre-exposure SARS-CoV-2-specific T cell repertoire determines the quality of the immune response to vaccination

C Saggau, GR Martini, E Rosati, S Meise, B Messner… - Immunity, 2022 - cell.com
spike-specific T cells, high interleukin-21 production, and specific immunoglobulin G, depended
on an intact naive repertoire … , as the T cell receptor (TCR) repertoire diversity providing …

Diagnosis and tracking of SARS-CoV-2 infection by T-cell receptor sequencing

RM Gittelman, E Lavezzo, TM Snyder, HJ Zahid… - MedRxiv, 2020 - medrxiv.org
T-cell receptor repertoire structure in terms of both diversity (breadth) and frequency (depth)
to SARS-CoV-2 … of one test and spike specific T-cell response, we take the non-spike protein …