[HTML][HTML] Analysis of therapeutic targets for SARS-CoV-2 and discovery of potential drugs by computational methods

C Wu, Y Liu, Y Yang, P Zhang, W Zhong… - … Pharmaceutica Sinica B, 2020 - Elsevier
target were predicted. This study will provide new lead compounds and targets for further in
vitro and in vivo studies of SARS-CoV-2, … drug repositioning to treat SARS-CoV-2 infections. …

Druggable targets of SARS-CoV-2 and treatment opportunities for COVID-19

BK Kumar, KVGC Sekhar, S Kunjiappan, J Jamalis… - Bioorganic …, 2020 - Elsevier
… like SARS, MERS, and Ebola. This review presents a critical analysis of druggable targets
of SARS CoV-2, new drug discovery, development, and treatment opportunities for COVID-19. …

[HTML][HTML] Targets of T cell responses to SARS-CoV-2 coronavirus in humans with COVID-19 disease and unexposed individuals

A Grifoni, D Weiskopf, SI Ramirez, J Mateus, JM Dan… - Cell, 2020 - cell.com
COVID-19 convalescent patients, respectively. CD4 + T cell responses to spike, the main
target … and correlated with the magnitude of the anti-SARS-CoV-2 IgG and IgA titers. The M, …

Potential drug targets of SARS-CoV-2: From genomics to therapeutics

A Shamsi, T Mohammad, S Anwar, S Amani… - International Journal of …, 2021 - Elsevier
… are crucial for binding to ACE2, five differ from SARS-CoV [27]. The similarity between S
protein of SARS-CoV-2, SARS CoV, and MERS CoV is that in all these it exists in homologous …

SARS-CoV-2 infectivity and neurological targets in the brain

WJ Lukiw, A Pogue, JM Hill - Cellular and molecular neurobiology, 2022 - Springer
… in CoV-19 patients. To further our understanding of the mechanism and pathways of SARS-CoV-2
… -types and organ systems to SARS-CoV-2 attack in this communication we analyzed …

Is the kidney a target of SARS-CoV-2?

MA Martinez-Rojas, O Vega-Vega… - American Journal of …, 2020 - journals.physiology.org
… respiratory syndrome-coronavirus 2 (SARS-CoV-2) represents … is compelling evidence that
novel SARS-CoV-2 is a highly … Like other coronaviruses, SARS-CoV-2 recognizes human …

[HTML][HTML] Role of structural and non-structural proteins and therapeutic targets of SARS-CoV-2 for COVID-19

R Yadav, JK Chaudhary, N Jain, PK Chaudhary… - Cells, 2021 - mdpi.com
SARS-CoV-2 is a new strain of corona virus that has not been traced in humans previously.
In this review, we primarily focus on multiple features of SARS-CoV-2… molecular targets, …

Structural features of coronavirus SARS-CoV-2 spike protein: Targets for vaccination

A Sternberg, C Naujokat - Life sciences, 2020 - Elsevier
… -driven entry into simian Vero target cells [16]. Sera from mice immunized with a stabilized
SARS-CoV S protein also significantly inhibited cell entry of SARS-CoV-2 into target cells [19], …

Immunoinformatic analysis of SARS-CoV-2 nucleocapsid protein and identification of COVID-19 vaccine targets

SC Oliveira, MTQ de Magalhaes… - Frontiers in immunology, 2020 - frontiersin.org
… In this study, we focus on the SARS-CoV-2 nucleocapsid protein as a suitable candidate
target for vaccine formulations. Major B and T cell epitopes of the SARS-CoV-2 N protein are …

Current status of antivirals and druggable targets of SARS CoV-2 and other human pathogenic coronaviruses

A Artese, V Svicher, G Costa, R Salpini… - Drug Resistance …, 2020 - Elsevier
… for SARS-CoV-1 and 34.4 % for MERS-CoV. More recently, the severe acute respiratory
syndrome coronavirus virus 2 (SARS-CoV-2… agent of the recent COVID-19 pandemic outbreak. It …