… like SARS, MERS, and Ebola. This review presents a critical analysis of druggable targets of SARSCoV-2, new drug discovery, development, and treatment opportunities for COVID-19. …
… COVID-19 convalescent patients, respectively. CD4 + T cell responses to spike, the main target … and correlated with the magnitude of the anti-SARS-CoV-2 IgG and IgA titers. The M, …
… are crucial for binding to ACE2, five differ from SARS-CoV [27]. The similarity between S protein of SARS-CoV-2, SARSCoV, and MERSCoV is that in all these it exists in homologous …
WJ Lukiw, A Pogue, JM Hill - Cellular and molecular neurobiology, 2022 - Springer
… in CoV-19 patients. To further our understanding of the mechanism and pathways of SARS-CoV-2 … -types and organ systems to SARS-CoV-2 attack in this communication we analyzed …
… respiratory syndrome-coronavirus2 (SARS-CoV-2) represents … is compelling evidence that novel SARS-CoV-2 is a highly … Like other coronaviruses, SARS-CoV-2 recognizes human …
… SARS-CoV-2 is a new strain of coronavirus that has not been traced in humans previously. In this review, we primarily focus on multiple features of SARS-CoV-2… molecular targets, …
A Sternberg, C Naujokat - Life sciences, 2020 - Elsevier
… -driven entry into simian Vero target cells [16]. Sera from mice immunized with a stabilized SARS-CoV S protein also significantly inhibited cell entry of SARS-CoV-2 into target cells [19], …
… In this study, we focus on the SARS-CoV-2 nucleocapsid protein as a suitable candidate target for vaccine formulations. Major B and T cell epitopes of the SARS-CoV-2 N protein are …
A Artese, V Svicher, G Costa, R Salpini… - Drug Resistance …, 2020 - Elsevier
… for SARS-CoV-1 and 34.4 % for MERS-CoV. More recently, the severe acute respiratory syndrome coronavirus virus 2 (SARS-CoV-2… agent of the recent COVID-19 pandemic outbreak. It …