The total number and mass of SARS-CoV-2 virions

R Sender, YM Bar-On, S Gleizer… - Proceedings of the …, 2021 - National Acad Sciences
… Combining this estimate with the measurement of viral concentration within the lung
tissue and accounting for 30 to 40 spike trimers on each SARS-CoV-2 virion (43, 44), we can …

Structures and distributions of SARS-CoV-2 spike proteins on intact virions

Z Ke, J Oton, K Qu, M Cortese, V Zila, L McKeane… - Nature, 2020 - nature.com
… the virion surface. To avoid artefacts associated with virus concentration or purification,
we aimed to image SARS-CoV-2 virions … Vero E6 cells were infected with SARS-CoV-2 (isolate …

A multiscale coarse-grained model of the SARS-CoV-2 virion

A Yu, AJ Pak, P He, V Monje-Galvan, L Casalino… - Biophysical journal, 2021 - cell.com
SARS-CoV-2 virion and details our multiscale approach toward model refinement. The
resulting model and methods can be applied to and enable the simulation of SARS-CoV-2 virions

The architecture of the SARS-CoV-2 RNA genome inside virion

C Cao, Z Cai, X Xiao, J Rao, J Chen, N Hu… - Nature …, 2021 - nature.com
… RNA genome of SARS-CoV-2 is folded in the tiny virion, we … global conformation of the
SARS-CoV-2 genome. Pursuing this, … to infer the 3D structure of SARS-CoV-2 39 . Our modeling …

Effect of inactivation methods on SARS-CoV-2 virion protein and structure

EK Loveday, KS Hain, I Kochetkova, JF Hedges… - Viruses, 2021 - mdpi.com
… to virion components. The goal of this study was to validate two methods of SARS-CoV-2
inactivation… —and assess their respective effects on virion components. We observed that both …

Topography, spike dynamics and nanomechanics of individual native SARS-CoV-2 virions

B Kiss, Z Kis, B Pályi, MS Kellermayer - Biophysical Journal, 2021 - cell.com
virion, however, remain unknown. by imaging and mechanically manipulating individual,
native SARS-CoV-2 virions … The virions are highly compliant and able to recover from drastic …

Supramolecular organization of SARS-CoV and SARS-CoV-2 virions revealed by coarse-grained models of intact virus envelopes

B Wang, C Zhong, DP Tieleman - Journal of chemical information …, 2021 - ACS Publications
… acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has a high sequence and architecture
identity with SARS-CoV, but far more people have been infected by SARS-CoV-2. Here, …

[HTML][HTML] Molecular architecture of the SARS-CoV-2 virus

H Yao, Y Song, Y Chen, N Wu, J Xu, C Sun, J Zhang… - Cell, 2020 - cell.com
… the COVID-19 pandemic. Despite recent advances in the structural elucidation of SARS-CoV-2
proteins… Here we report the molecular assembly of the authentic SARS-CoV-2 virus using …

Atomic force microscopy analysis of native infectious and inactivated SARS-CoV-2 virions

S Lyonnais, M Hénaut, A Neyret, P Merida… - Scientific Reports, 2021 - nature.com
… In conclusion, in front of the urgent need to perform researches on SARS-CoV-2 to fight
COVID-19, the inactivation methods described here can contribute to transfer the virion from the …

SARS-CoV-2 spike-protein D614G mutation increases virion spike density and infectivity

L Zhang, CB Jackson, H Mou, A Ojha, H Peng… - Nature …, 2020 - nature.com
… on the virion surface to give the appearance of a crown (corona in Latin). The coronavirus S
… receptor binding and the S2 mediates downstream membrane fusion 1,2 . The receptor for …