Y Cao, L Li, Z Feng, S Wan, P Huang, X Sun, F Wen… - Cell discovery, 2020 - nature.com
… The ACE2 gene encodes the angiotensin-converting enzyme-2, which has been proved to … for both the SARS-coronavirus (SARS-CoV) and the human respiratory coronavirus NL63. …
… that SARS-CoV-2/ACE2 binding has on the renin–angiotensin system and beyond. Indeed, although mostly neglected, ACE2 … Thorough comprehension of the role that ACE2 plays in …
AR Bourgonje, AE Abdulle, W Timens… - The Journal of …, 2020 - Wiley Online Library
… Since identifying the exact role of ACE2 and SARS-CoV-2 in COVID-19 may … COVID-19. Furthermore, we highlight a selection of currently considered treatment modalities for COVID-19. …
P Verdecchia, C Cavallini, A Spanevello… - European journal of …, 2020 - Elsevier
… We suggest that ACE2 down-regulation induced by the cell entry of SARS-CoV, NL63 and SARS-CoV-2 may be particularly detrimental in subjects with pre-existing ACE2 deficiency. …
S Lukassen, RL Chua, T Trefzer, NC Kahn… - The EMBO …, 2020 - embopress.org
… Coronavirus entry requires its binding to host cell receptor ACE2 and subsequent priming by TMPRSS2… expression of potential SARS‐CoV‐2 cofactors ACE2, TMPRSS2 and FURIN …
J Chen, Q Jiang, X Xia, K Liu, Z Yu, W Tao, W Gong… - Aging cell, 2020 - Wiley Online Library
… at ACE2 regulatory regions. Human and mice data analysis further revealed ACE2 expression is … Our findings revealed a negative correlation between ACE2 expression and COVID-19 …
Q Wang, Y Zhang, L Wu, S Niu, C Song, Z Zhang, G Lu… - Cell, 2020 - cell.com
… Recently, ACE2 was reported as an entry receptor for SARS-CoV-2. In this study, we … domain of SARS-CoV-2 (SARS-CoV-2-CTD) spike (S) protein in complex with human ACE2 (hACE2…
A Ali, R Vijayan - Scientific reports, 2020 - nature.com
… Evaluation of the binding of SARS-CoV-2 and SARS-CoV RBDs with ACE2 have revealed more hydrogen bonds and electrostatic interactions in SARS-CoV-2 10,12 . These findings …
Y Li, W Zhou, L Yang, R You - Pharmacological research, 2020 - Elsevier
… Recently, ACE2 was identified as the receptor of severe acute … coronavirus2 (SARS-CoV-2), the coronavirus that is causing the pandemic of Coronavirus disease 2019 (COVID-19). …