… and that many of the key interactions of the active conformation of the enzyme around the
active site are lost. Solvation/ desolvation energetic contributions play an important role in the …

… SARS coronavirus (SARS-CoV) was identified as the etiological agent of the pandemic …
acute respiratory syndrome (SARS). During the outbreak in 2003, SARS-CoV infected more than …

… active conformation. However, there is an equilibrium between the inactive monomer and
active … Most studies have focused on the active dimeric M pro , with the development of antiviral …

… and summarize the diversity of active site flexible conformations in our SARS-CoV-2 3CL …
The final six PPCs obtained represent all of the diverse conformations of active sites occurring …

… The S protein undergoes a clockwise twist from the locked conformation to the active
conformation when looked from the S protein to the viral membrane, which loosens the NTD and …

… SARS coronavirus (SARS-CoV) is the etiological agent of the … severe acute respiratory
syndrome (SARS) outbreak in 2003 (… active conformation in a super-active octamer of SARS-CoV …

… active conformation is stabilized by the interaction between the substrate and main-chain
atoms of Gly143 and Cys145. In active conformations of … for the active conformation and ligand …

… characterize the conformational fluctuations and interdomain interactions of SARS-CoV-2 …
are rearranged in the conformational transition from the inactive to the active forms, which is …

… binding of such inhibitors to the active site of MPro precursor prior … SARS CoV isolate and
not to the recent SARS CoV-2 MPro.22, 23 A recent study aiming to address the conformation …

… The N-finger plays an important role in the formation of the active site and auto cleavage …
protomer, stabilizing the active site and dimer in the active conformation, while the electron …