Adenoviral vector vaccine platforms in the SARS-CoV-2 pandemic

SA Mendonça, R Lorincz, P Boucher, DT Curiel - npj Vaccines, 2021 - nature.com
adenoviral vector systems. These successes and the urgency of the COVID-19 situation
have resulted in a flurry of candidate adenoviral vector … This review details adenoviral vector

… after vaccination against SARS-CoV-2 may be derived from a combined effect of SARS-CoV-2 spike protein and adenovirus vector-triggered signaling pathways

R Kircheis - International journal of molecular sciences, 2021 - mdpi.com
SARS-CoV-2 encapsulated in lipid nanoparticles and two adenoviral vector-based vaccines,
ie, ChAdOx1 nCoV… chimpanzee adenoviral vector encoding the spike protein of SARS-CoV-…

[HTML][HTML] Adenoviral vector DNA-and SARS-CoV-2 mRNA-based Covid-19 vaccines: possible integration into the human genome-are adenoviral genes expressed in …

W Doerfler - Virus research, 2021 - Elsevier
… events of adenovirus vector or of SARS-CoV-2 RNA reverse transcript DNA at low
frequency versus hopefully high vaccine efficacy and protection. Moreover, since SARS-CoV-2 …

A single dose of an adenovirus-vectored vaccine provides protection against SARS-CoV-2 challenge

S Wu, G Zhong, J Zhang, L Shuai, Z Zhang… - Nature …, 2020 - nature.com
… replication-defective human type 5 adenovirus encoding the SARS-CoV-2 spike protein (Ad5-nCoV)
protect mice completely against mouse-adapted SARS-CoV-2 infection in the upper …

Comparison of neutralizing antibody titers elicited by mRNA and adenoviral vector vaccine against SARS-CoV-2 variants

T Tada, H Zhou, MI Samanovic, BM Dcosta… - BioRxiv, 2021 - biorxiv.org
… mRNA-based and an adenoviral vector-based vaccine against … acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) … (Pfizer and Moderna) and adenoviral vector-based (Johnson & …

Humoral response to mRNA versus an adenovirus vector-based SARS-CoV-2 vaccine in dialysis patients

JG Mulhern, A Fadia, R Patel… - Clinical Journal of the …, 2021 - journals.lww.com
Patients on maintenance dialysis may be immunocompromised and have comorbidities that
modulate the response to coronavirus disease 2019 (COVID-19) vaccines. We conducted a …

Comparison of transgenic and adenovirus hACE2 mouse models for SARS-CoV-2 infection

R Rathnasinghe, S Strohmeier, F Amanat… - Emerging microbes & …, 2020 - Taylor & Francis
… facility for intranasal instillation of non-replicating adenoviral (Ad) vectors before being
transferred to a BSL-3 facility at ISMMS for challenge with SARS-CoV-2. Mice were housed under …

Manufacturing a chimpanzee adenovirus‐vectored SARSCoV‐2 vaccine to meet global needs

CCD Joe, J Jiang, T Linke, Y Li… - Biotechnology and …, 2022 - Wiley Online Library
… ChAdOx1 nCoV-19 (AZD1222, Vaxzevria) is an efficacious vaccine against SARS-CoV-2,
based upon an adenovirus vector. We describe the development of a process for the …

[HTML][HTML] Comparative analysis of ChAdOx1 nCoV-19 and Ad26. COV2. S SARS-CoV-2 vector vaccines

S Michalik, F Siegerist, R Palankar, K Franzke… - …, 2022 - ncbi.nlm.nih.gov
… -2 spike protein was detected only in the ChAdOx1 nCoV-19 vaccine. There may be several
… of the SARS-CoV-2 transgene during the production of the recombinant adenoviral vectors. …

Neutralization of SARS-CoV-2 variants by mRNA and adenoviral vector vaccine-elicited antibodies

T Tada, H Zhou, MI Samanovic, BM Dcosta… - Frontiers in …, 2022 - frontiersin.org
The increasing prevalence of SARS-CoV-2 variants has raised concerns regarding possible
decreases in vaccine effectiveness. Here, neutralizing antibody titers elicited by mRNA-…