Benefits and limitations of serological assays in COVID-19 infection

Z Sidiq, M Hanif, KK Dwivedi, KK Chopra - indian journal of tuberculosis, 2020 - Elsevier
… It was shown that among these antigens tested, S1 was more specific in detecting SARS-CoV-2
antibodies while N protein was more sensitive than S1. While describing an ELISA …

[HTML][HTML] Multivalency transforms SARS-CoV-2 antibodies into ultrapotent neutralizers

E Rujas, I Kucharska, YZ Tan, S Benlekbir… - Nature …, 2021 - nature.com
… against viruses with low surface spike density like HIV-1 46 , or against other targets like the
tumor necrosis factor receptor superfamily, where bivalency of conventional antibodies limits

[HTML][HTML] Point-of-care diagnostic tests for detecting SARS-CoV-2 antibodies: a systematic review and meta-analysis of real-world data

M Ricco, P Ferraro, G Gualerzi, S Ranzieri… - Journal of Clinical …, 2020 - mdpi.com
… our results, some significant limitations should be stressed. First … of available POCT for
SARS-CoV-2 antibodies is currently … However, given the limitations of the present review, such as …

[HTML][HTML] Performance of a SARS CoV-2 antibody ELISA based on simultaneous measurement of antibodies against the viral nucleoprotein and receptor-binding …

N Reiners, C Schnurra, H Trawinski… - European Journal of …, 2021 - Springer
… lower limits of … SARS CoV-2 RBD-specific antibody ELISA was diagnostically more sensitive
than the NP-specific ELISA. Simultaneous measurement of NP- and RBD-specific antibodies

Diagnostic performances and thresholds: The key to harmonization in serological SARS-CoV-2 assays?

M Plebani, A Padoan, D Negrini, B Carpinteri… - Clinica chimica acta, 2020 - Elsevier
… The evaluation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) specific
antibody (Ab) assay performances is of the … The present study has some limitations. First, …

Prevalence of antibodies to SARS-CoV-2 in Irish hospital healthcare workers

N Allen, UN Riain, N Conlon, A Ferenczi… - Epidemiology & …, 2021 - cambridge.org
antibody levels below the limits of detection of the test. We feel that a false-positive PCR
result is less likely, but also possible. In both hospitals, the seroprevalence was higher than the …

[HTML][HTML] The rapid coronavirus antibody test: can we improve accuracy?

IP Pavlova, SS Nair, N Kyprianou, AK Tewari - Frontiers in Medicine, 2020 - frontiersin.org
Antibody tests check for an antibody response to SARS-CoV-… Effective laboratory SARS-CoV-2
antibody technologies have … some of the limitations of rapid COVID-19 antibody tests and …

[HTML][HTML] The kinetics of viral load and antibodies to SARS-CoV-2

J Sun, X Tang, R Bai, C Liang, L Zeng, H Lin… - Clinical Microbiology …, 2020 - Elsevier
Objectives The aim was to understand persistence of the virus in body fluids the and
immune response of an infected host to severe acute respiratory syndrome coronavirus-2 (SARS-…

[HTML][HTML] Fc-engineered antibody therapeutics with improved anti-SARS-CoV-2 efficacy

R Yamin, AT Jones, HH Hoffmann, A Schäfer, KS Kao… - Nature, 2021 - nature.com
… of anti-SARS-CoV-2 monoclonal antibodies with optimized Fc … limits the therapeutic window
for monoclonal antibody treatment … Despite this limitation, we observed that in models of …

Antibody responses to SARS-CoV-2 in patients with novel coronavirus disease 2019

J Zhao, Q Yuan, H Wang, W Liu, X Liao… - Clinical infectious …, 2020 - academic.oup.com
limit the damage of the current outbreak. Our study provided robust evidence that (1) the acute
antibody response in patients with SARS-CoV-… , and (3) the total antibody (Ab) test is more …