… therapy may provide a powerful way to minimize mutational escape by SARS-CoV-2; in particular, our studies point to the potential value of antibodycocktails in which two antibodies …
KH Liang, PY Chiang, SH Ko, YC Chou, RM Lu… - Journal of Biomedical …, 2021 - Springer
… We next tested the therapeutic effects of the antibodycocktail administered after SARS-CoV-2 infection in the hamster model (Fig. 4). We treated hamsters with RBD-chAb-15 or -28 …
J Hansen, A Baum, KE Pascal, V Russo, S Giordano… - Science, 2020 - science.org
… approaches for generating antibodies to the RBD of the SARS-CoV-2 spike protein, … antibodies that we could meet our prospective goal of identifying highly potent individual antibodies …
N Wang, Y Sun, R Feng, Y Wang, Y Guo, L Zhang… - Cell research, 2021 - nature.com
… The CM5 sensor labeled with SARS-CoV-2 S trimer was saturated … SARS-CoV-2 S trimer, underlining the potential of these antibodies in formulating cooperative two-antibodycocktails …
Y Qu, X Zhang, M Wang, L Sun, Y Jiang, C Li, W Wu… - Virologica Sinica, 2021 - Springer
… of cocktailantibodies against constantly emerging SARS-CoV-2 variants and provided promising candidate antibodies … of COVID-19 patients infected with broad SARS-CoV-2 variants. …
… have strong neutralizing activity against SARS-CoV-2 and variants of … antibody features enable recognition of the SARS-CoV-2 spike RBD and demonstrate the utility of the cocktail …
DM Weinreich, S Sivapalasingam… - … England Journal of …, 2021 - Mass Medical Soc
… REGN-COV2, an antibodycocktail containing two SARS-CoV-2–neutralizing antibodies, in … and death from Covid-19 emanate from the SARS-CoV-2 viral burden and that reducing this …
DM Weinreich, S Sivapalasingam, T Norton, S Ali… - MedRxiv, 2021 - medrxiv.org
… to generate an antibodycocktail consisting of two SARS-CoV-2 neutralizing antibodies against distinct, non-overlapping epitopes on the spike protein, resulting in REGEN-COV. In vitro …
Y Sun, L Wang, R Feng, N Wang, Y Wang, D Zhu… - Cell research, 2021 - nature.com
… of the potential three- and four-antibodycocktails, we performed cryo-EM analysis of the SARS-CoV-2 S trimer in complex with two sets of multiple-antibodycocktails (FC05–H014–P17; …