Molecular determinants and mechanism for antibody cocktail preventing SARS-CoV-2 escape

Z Ku, X Xie, E Davidson, X Ye, H Su… - Nature …, 2021 - nature.com
… it doesn’t escape from the cocktail due to stronger mutational … shared between SARS-CoV-2
and SARS-CoV for antibody CoV2… of antibody cocktails as candidates for treating COVID-19. …

Antibody cocktail to SARS-CoV-2 spike protein prevents rapid mutational escape seen with individual antibodies

A Baum, BO Fulton, E Wloga, R Copin, KE Pascal… - Science, 2020 - science.org
… therapy may provide a powerful way to minimize mutational escape by SARS-CoV-2; in
particular, our studies point to the potential value of antibody cocktails in which two antibodies

Antibody cocktail effective against variants of SARS-CoV-2

KH Liang, PY Chiang, SH Ko, YC Chou, RM Lu… - Journal of Biomedical …, 2021 - Springer
… We next tested the therapeutic effects of the antibody cocktail administered after SARS-CoV-2
infection in the hamster model (Fig. 4). We treated hamsters with RBD-chAb-15 or -28 …

Studies in humanized mice and convalescent humans yield a SARS-CoV-2 antibody cocktail

J Hansen, A Baum, KE Pascal, V Russo, S Giordano… - Science, 2020 - science.org
… approaches for generating antibodies to the RBD of the SARS-CoV-2 spike protein, …
antibodies that we could meet our prospective goal of identifying highly potent individual antibodies

Structure-based development of human antibody cocktails against SARS-CoV-2

N Wang, Y Sun, R Feng, Y Wang, Y Guo, L Zhang… - Cell research, 2021 - nature.com
… The CM5 sensor labeled with SARS-CoV-2 S trimer was saturated … SARS-CoV-2 S trimer,
underlining the potential of these antibodies in formulating cooperative two-antibody cocktails

Antibody cocktail exhibits broad neutralization activity against SARS-CoV-2 and SARS-CoV-2 variants

Y Qu, X Zhang, M Wang, L Sun, Y Jiang, C Li, W Wu… - Virologica Sinica, 2021 - Springer
… of cocktail antibodies against constantly emerging SARS-CoV-2 variants and provided
promising candidate antibodies … of COVID-19 patients infected with broad SARS-CoV-2 variants. …

Genetic and structural basis for SARS-CoV-2 variant neutralization by a two-antibody cocktail

J Dong, SJ Zost, AJ Greaney, TN Starr… - Nature …, 2021 - nature.com
… have strong neutralizing activity against SARS-CoV-2 and variants of … antibody features
enable recognition of the SARS-CoV-2 spike RBD and demonstrate the utility of the cocktail

REGN-COV2, a neutralizing antibody cocktail, in outpatients with Covid-19

DM Weinreich, S Sivapalasingam… - … England Journal of …, 2021 - Mass Medical Soc
… REGN-COV2, an antibody cocktail containing two SARS-CoV-2–neutralizing antibodies, in
… and death from Covid-19 emanate from the SARS-CoV-2 viral burden and that reducing this …

REGEN-COV antibody cocktail clinical outcomes study in Covid-19 outpatients

DM Weinreich, S Sivapalasingam, T Norton, S Ali… - MedRxiv, 2021 - medrxiv.org
… to generate an antibody cocktail consisting of two SARS-CoV-2 neutralizing antibodies
against distinct, non-overlapping epitopes on the spike protein, resulting in REGEN-COV. In vitro …

Structure-based development of three-and four-antibody cocktails against SARS-CoV-2 via multiple mechanisms

Y Sun, L Wang, R Feng, N Wang, Y Wang, D Zhu… - Cell research, 2021 - nature.com
… of the potential three- and four-antibody cocktails, we performed cryo-EM analysis of the
SARS-CoV-2 S trimer in complex with two sets of multiple-antibody cocktails (FC05–H014–P17; …