[PDF][PDF] Structural changes in the SARS-CoV-2 spike E406W mutant escaping a clinical monoclonal antibody cocktail

A Addetia, YJ Park, T Starr, AJ Greaney, KR Sprouse… - Cell Reports, 2023 - cell.com
… syndrome coronavirus 2 (SARS-CoV-2) is eroding antibody … majority of neutralizing antibodies
elicited by SARS-CoV-2 … -variant neutralizing antibodies, and of monoclonal antibodies (…

Preclinical characterization of amubarvimab and romlusevimab, a pair of non-competing neutralizing monoclonal antibody cocktail, against SARS-CoV-2

Y Ji, Q Zhang, L Cheng, J Ge, R Wang, M Fang… - Frontiers in …, 2022 - frontiersin.org
… In a Syrian golden hamster model of SARS-CoV-2 infection, … their development as an antibody
cocktail therapeutic option … are valuable antibody cocktail for the treatment of COVID-19. …

Analysis of the molecular mechanism of SARS-CoV-2 antibodies

D Jin, J Wei, J Sun - Biochemical and biophysical research communications, 2021 - Elsevier
… of antibody cocktails against SARS-CoV-2 mutants. … use of RBD antibody and NTD antibody
as an antibody cocktail. And … antibodies may be better as antibody cocktail. The use of these …

[HTML][HTML] Speed and need: twin development challenges in rapid response for a SARS-CoV-2 antibody cocktail

A Lehman, VA Muñiz, R Chaney, J Pimentel… - Current Opinion in …, 2022 - Elsevier
… The result has been the REGEN-COVcocktail consisting of the casirivimab and imdevimab
monoclonal antibodies currently with emergency use authorization (EUA) or commercial …

Structure-guided antibody cocktail for prevention and treatment of COVID-19

SC Su, TJ Yang, PY Yu, KH Liang, WY Chen… - PLoS …, 2021 - journals.plos.org
… We next tested the effect of treating animals with the antibody cocktail post SARS-CoV-2
infection. We treated the AAV-hACE2 mouse model with combinations of 1.5, 4.5, or 10 mg/kg of …

[PDF][PDF] Rational identification of potent and broad sarbecovirus-neutralizing antibody cocktails from SARS convalescents

Y Cao, F Jian, Z Zhang, A Yisimayi, X Hao, L Bao… - Cell reports, 2022 - cell.com
antibody library needed, we choose SARS-CoV-2-vaccinated SARS convalescents as the
antibody … large bsNAb collection from SARSCoV-2-vaccinated SARS convalescents with each …

Ultrapotent human antibodies protect against SARS-CoV-2 challenge via multiple mechanisms

MA Tortorici, M Beltramello, FA Lempp, D Pinto… - Science, 2020 - science.org
Antibody cocktails that include S2M11, S2E12, or the previously identified S309 antibody
broadly neutralize a panel of circulating SARS-CoV-… the way to implement antibody cocktails for …

Fc-engineered antibody therapeutics with improved anti-SARS-CoV-2 efficacy

R Yamin, AT Jones, HH Hoffmann, A Schäfer, KS Kao… - Nature, 2021 - nature.com
… Similar results were obtained when we assessed the in vivo therapeutic activity of another
neutralizing anti-SARS-CoV-2 monoclonal antibody cocktail 27 (C135 + C144 (also known as …

[HTML][HTML] ZRC3308 monoclonal antibody cocktail shows protective efficacy in Syrian hamsters against SARS-CoV-2 infection

PD Yadav, SK Mendiratta, S Mohandas, AK Singh… - Viruses, 2021 - mdpi.com
… The mAb cocktail demonstrated effective prophylactic and therapeutic activity against
SARS-CoV-2 infection in Syrian hamsters. The antibody cocktail appears to be a promising …

REGN-COV2 antibodies prevent and treat SARS-CoV-2 infection in rhesus macaques and hamsters

A Baum, D Ajithdoss, R Copin, A Zhou, K Lanza… - Science, 2020 - science.org
… -COV2, a cocktail of two potent neutralizing antibodies (REGN10987 … coronavirus 2 (SARS-CoV-2)
spike protein. In this report, we evaluate the in vivo efficacy of this antibody cocktail in …