[PDF][PDF] The monoclonal antibody combination REGEN-COV protects against SARS-CoV-2 mutational escape in preclinical and human studies

R Copin, A Baum, E Wloga, KE Pascal, S Giordano… - Cell, 2021 - cell.com
… Treatment with monoclonal antibody combinations limits generation of SARSCoV-2 escape
variants in humans and model animals and protects against current variants of concern. …

[HTML][HTML] REGEN-COV antibody combination and outcomes in outpatients with Covid-19

DM Weinreich, S Sivapalasingam… - … England Journal of …, 2021 - Mass Medical Soc
… trial, REGEN-COV, a combination of the monoclonal antibodies casirivimab and … COV
has activity in vitro against current severe acute respiratory syndrome coronavirus 2 (SARS-CoV

[HTML][HTML] Subcutaneous REGEN-COV antibody combination to prevent Covid-19

MP O'Brien, E Forleo-Neto, BJ Musser… - … England Journal of …, 2021 - Mass Medical Soc
… ongoing exposure to a person infected with SARS-CoV-2. We used a household-contact
trial design to assess whether REGEN-COV could prevent SARS-CoV-2 infection in a scenario …

[HTML][HTML] Cross-neutralization of SARS-CoV-2 by a human monoclonal SARS-CoV antibody

D Pinto, YJ Park, M Beltramello, AC Walls, MA Tortorici… - Nature, 2020 - nature.com
… of neutralizing antibodies. Here we describe several monoclonal antibodies that target the S
glycoprotein of SARS-CoV-2, … Antibody cocktails that include S309 in combination with other …

[HTML][HTML] Human monoclonal antibody combination against SARS coronavirus: synergy and coverage of escape mutants

J Ter Meulen, EN Van Den Brink, LLM Poon… - PLoS …, 2006 - journals.plos.org
SARS-CoV infection by subneutralizing antibody concentrations is of concern, we show here
that anti-SARS-CoV antibodies … human macrophages by SARS-CoV into a productive one. …

Antibody potency, effector function, and combinations in protection and therapy for SARS-CoV-2 infection in vivo

A Schäfer, F Muecksch, JCC Lorenzi, SR Leist… - Journal of Experimental …, 2020 - rupress.org
… antiviral potency and can prevent the emergence of antibody escape mutations (Hansen et
al.… benefit of antibody combinations for in vivo protection, we tested mixtures of antibodies that …

[HTML][HTML] Subcutaneous REGEN-COV antibody combination in early asymptomatic SARS-Cov-2 infection: a randomized clinical trial

MP O'Brien, E Forleo-Neto, N Sarkar, F Isa, P Hou… - MedRxiv, 2021 - ncbi.nlm.nih.gov
… on the SARS-CoV-2 spike protein receptor binding domain and block virus entry. The two-antibody
combination reduces the risk of emergence of treatment-induced SARS-CoV-2 …

Monoclonal antibody therapies against SARS-CoV-2

D Focosi, S McConnell, A Casadevall… - The Lancet Infectious …, 2022 - thelancet.com
… Monoclonal antibodies (mAbs) targeting the spike protein of SARS-CoV-2 have been widely
used in … REGEN-COV antibody combination and outcomes in outpatients with COVID-19. …

[HTML][HTML] Molecular determinants and mechanism for antibody cocktail preventing SARS-CoV-2 escape

Z Ku, X Xie, E Davidson, X Ye, H Su… - Nature …, 2021 - nature.com
Antibody cocktails represent a promising approach to prevent SARS-CoV-2 escape. The
determinants for selecting antibody combinations and the mechanism that antibody cocktails …

Antibody cocktail to SARS-CoV-2 spike protein prevents rapid mutational escape seen with individual antibodies

A Baum, BO Fulton, E Wloga, R Copin, KE Pascal… - Science, 2020 - science.org
… for the loss of SARS-CoV-2 neutralization by the antibodies, we generated VSV-SARS-CoV-2
spike … Two or more anti-SARS-CoV-2 spike RBD antibody combination can strengthen …