DM Weinreich, S Sivapalasingam… - … England Journal of …, 2021 - Mass Medical Soc
… trial, REGEN-COV, a combination of the monoclonal antibodies casirivimab and … COV has activity in vitro against current severe acute respiratory syndrome coronavirus 2 (SARS-CoV…
MP O'Brien, E Forleo-Neto, BJ Musser… - … England Journal of …, 2021 - Mass Medical Soc
… ongoing exposure to a person infected with SARS-CoV-2. We used a household-contact trial design to assess whether REGEN-COV could prevent SARS-CoV-2 infection in a scenario …
… of neutralizing antibodies. Here we describe several monoclonal antibodies that target the S glycoprotein of SARS-CoV-2, … Antibody cocktails that include S309 in combination with other …
J Ter Meulen, EN Van Den Brink, LLM Poon… - PLoS …, 2006 - journals.plos.org
… SARS-CoV infection by subneutralizing antibody concentrations is of concern, we show here that anti-SARS-CoVantibodies … human macrophages by SARS-CoV into a productive one. …
… antiviral potency and can prevent the emergence of antibody escape mutations (Hansen et al.… benefit of antibodycombinations for in vivo protection, we tested mixtures of antibodies that …
MP O'Brien, E Forleo-Neto, N Sarkar, F Isa, P Hou… - MedRxiv, 2021 - ncbi.nlm.nih.gov
… on the SARS-CoV-2 spike protein receptor binding domain and block virus entry. The two-antibody combination reduces the risk of emergence of treatment-induced SARS-CoV-2 …
… Monoclonal antibodies (mAbs) targeting the spike protein of SARS-CoV-2 have been widely used in … REGEN-COVantibodycombination and outcomes in outpatients with COVID-19. …
… Antibody cocktails represent a promising approach to prevent SARS-CoV-2 escape. The determinants for selecting antibodycombinations and the mechanism that antibody cocktails …
… for the loss of SARS-CoV-2 neutralization by the antibodies, we generated VSV-SARS-CoV-2 spike … Two or more anti-SARS-CoV-2 spike RBD antibodycombination can strengthen …