Antibody cocktail to SARS-CoV-2 spike protein prevents rapid mutational escape seen with individual antibodies

A Baum, BO Fulton, E Wloga, R Copin, KE Pascal… - Science, 2020 - science.org
… for the loss of SARS-CoV-2 neutralization by the antibodies, we generated VSV-SARS-CoV-2
spike … Two or more anti-SARS-CoV-2 spike RBD antibody combination can strengthen …

The SARS-CoV-2 monoclonal antibody combination, AZD7442, is protective in nonhuman primates and has an extended half-life in humans

YM Loo, PM McTamney, RH Arends… - Science translational …, 2022 - science.org
… of the SARS-CoV-2 spike protein and have been modified to have an extended half-life. The
antibody combination protected nonhuman primates from infection with SARS-CoV-2 when …

[HTML][HTML] SARS-CoV-2 variant evasion of monoclonal antibodies based on in vitro studies

MG Cox, TP Peacock, WT Harvey, J Hughes… - Nature Reviews …, 2023 - nature.com
… For cocktails of mAbs consisting of non-competing antibodies that target different regions
of SARS-CoV-2 spike protein, resistance was found to occur whenever the combination of …

[HTML][HTML] Structure-based development of human antibody cocktails against SARS-CoV-2

N Wang, Y Sun, R Feng, Y Wang, Y Guo, L Zhang… - Cell research, 2021 - nature.com
… HB27, are pan-SARS-CoVs cross-reactive and SARS-CoV-2-… conferred effective protection
against SARS-CoV-2 in animal … -antibody cocktails of the NTD-targeting FC05 in combination

… casirivimab and imdevimab antibody combination vs placebo on development of symptomatic COVID-19 in early asymptomatic SARS-CoV-2 infection: a randomized …

MP O'Brien, E Forleo-Neto, N Sarkar, F Isa, P Hou… - Jama, 2022 - jamanetwork.com
… -CoV-2 spike protein receptor–binding domain and block virus entry. The 2-antibody
combination reduces the risk of emergence of treatment-induced SARS-CoV-2 variants and retains …

[HTML][HTML] Low-dose in vivo protection and neutralization across SARS-CoV-2 variants by monoclonal antibody combinations

V Dussupt, RS Sankhala, L Mendez-Rivera… - Nature …, 2021 - nature.com
… of neutralizing antibodies elicited by SARS-CoV-2 … SARS-CoV-2-specific CD19 + B cells
with a broad range of specificities. The first sorting strategy used a combination of SARS-CoV-2 (…

[HTML][HTML] In vivo monoclonal antibody efficacy against SARS-CoV-2 variant strains

RE Chen, ES Winkler, JB Case, ID Aziati, TL Bricker… - Nature, 2021 - nature.com
… , COV2-2130/COV2-2196 and REGN10933/REGN10987 combinations prevented infection
and inflammation caused by the different SARS-CoV-2 strains, we tested a tenfold-lower (4 …

[HTML][HTML] Antibody resistance of SARS-CoV-2 variants B. 1.351 and B. 1.1. 7

P Wang, MS Nair, L Liu, S Iketani, Y Luo, Y Guo… - Nature, 2021 - nature.com
… in which B.1.351 and related variants 13,14 are prevalent, and highlight the importance
of combination antibody therapy to address the expanding antigenic diversity of SARS-CoV-2. …

Ultrapotent antibodies against diverse and highly transmissible SARS-CoV-2 variants

L Wang, T Zhou, Y Zhang, ES Yang, CA Schramm… - Science, 2021 - science.org
… We evaluated these antibodies individually or in combinations for their capacity to prevent
rcVSV-SARS2 escape and discovered that antibody combinations with complementary modes …

[HTML][HTML] Antibody cocktail effective against variants of SARS-CoV-2

KH Liang, PY Chiang, SH Ko, YC Chou, RM Lu… - Journal of Biomedical …, 2021 - Springer
antibodies and their combinations were confirmed in SARS-… our antibodies in a hamster
model of mild human SARS-CoV-… combination (1.5 mg/kg each) were made one day prior to WT …