… Strikingly, all four combination monoclonal antibody drugs in clinical use lost substantial activity against B.1.1.529, probably abolishing or impairing their efficacy in patients. …
Z Li, Y Yi, X Luo, N Xiong, Y Liu, S Li… - Journal of medical …, 2020 - Wiley Online Library
… SARS outbreak, we assume its antibody generation process is similar, and detection of the IgG and IgM antibody against SARS-CoV… We believe the combination of nucleic acid RT-PCR …
… Combination of three different antibody specificities and the fragment crystallizable (Fc) domain on a single multivalent molecule conferred the ability to overcome viral sequence …
S Wang, H Sun, Y Zhang, L Yuan, Y Wang, T Zhang… - Cell reports, 2022 - cell.com
… This structural feature indicates the synergistic effect of these antibodies when administered in combination. To test the potential synergistic neutralization of antibodycombinations …
RR De Assis, A Jain, R Nakajima, A Jasinskas… - Nature …, 2021 - nature.com
… In order to rank the individual antigens and combinations of antigens from SARS-CoV-2 for performance in discriminating the positive and negative groups, the receiver operating …
… effectiveness of SARS-CoV-2-specific neutralising monoclonal antibodies, hyperimmune … participants with or without potential exposure to SARS-CoV-2. The RCTs were identified from …
The emergence of Coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 made imperative the need for diagnostic tests that can identify the infection. Although Nucleic Acid …
R Wang, Q Zhang, R Zhang, ZQ Aw, P Chen… - Frontiers in …, 2022 - frontiersin.org
… We next studied the binding activity of these antibodies individually or in combination to the spike protein of the three Omicron variants expressed on the surface of HEK293T (Figure 2). …
… However, combinations of antibodies remained effective against all of the variants we tested, which confirms the importance of using combinations of antibodies in the clinic (Extended …