Monoclonal antibodies against SARS-CoV-2: current scenario and future perspectives

E Quiros-Roldan, S Amadasi, I Zanella, M Degli Antoni… - Pharmaceuticals, 2021 - mdpi.com
… infected with SARS-CoV-2 because of occurrence of SARS-CoV-2 … SARS-CoV-2 infection
in a rhesus macaque model are associated to the combination of two long-acting antibodies (…

Striking antibody evasion manifested by the Omicron variant of SARS-CoV-2

L Liu, S Iketani, Y Guo, JFW Chan, M Wang, L Liu… - Nature, 2022 - nature.com
… Strikingly, all four combination monoclonal antibody drugs in clinical use lost substantial
activity against B.1.1.529, probably abolishing or impairing their efficacy in patients. …

Development and clinical application of a rapid IgM‐IgG combined antibody test for SARSCoV‐2 infection diagnosis

Z Li, Y Yi, X Luo, N Xiong, Y Liu, S Li… - Journal of medical …, 2020 - Wiley Online Library
SARS outbreak, we assume its antibody generation process is similar, and detection of the
IgG and IgM antibody against SARS-CoV… We believe the combination of nucleic acid RT-PCR …

Multivalency transforms SARS-CoV-2 antibodies into ultrapotent neutralizers

E Rujas, I Kucharska, YZ Tan, S Benlekbir… - Nature …, 2021 - nature.com
Combination of three different antibody specificities and the fragment crystallizable (Fc)
domain on a single multivalent molecule conferred the ability to overcome viral sequence …

[PDF][PDF] Three SARS-CoV-2 antibodies provide broad and synergistic neutralization against variants of concern, including Omicron

S Wang, H Sun, Y Zhang, L Yuan, Y Wang, T Zhang… - Cell reports, 2022 - cell.com
… This structural feature indicates the synergistic effect of these antibodies when administered
in combination. To test the potential synergistic neutralization of antibody combinations

Analysis of SARS-CoV-2 antibodies in COVID-19 convalescent blood using a coronavirus antigen microarray

RR De Assis, A Jain, R Nakajima, A Jasinskas… - Nature …, 2021 - nature.com
… In order to rank the individual antigens and combinations of antigens from SARS-CoV-2
for performance in discriminating the positive and negative groups, the receiver operating …

Determinants of passive antibody efficacy in SARS-CoV-2 infection

E Stadler, KL Chai, TE Schlub, D Cromer… - medrxiv, 2022 - medrxiv.org
… effectiveness of SARS-CoV-2-specific neutralising monoclonal antibodies, hyperimmune …
participants with or without potential exposure to SARS-CoV-2. The RCTs were identified from …

Antibody tests in detecting SARS-CoV-2 infection: a meta-analysis

PI Kontou, GG Braliou, NL Dimou, G Nikolopoulos… - Diagnostics, 2020 - mdpi.com
The emergence of Coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 made
imperative the need for diagnostic tests that can identify the infection. Although Nucleic Acid …

SARS-CoV-2 Omicron variants reduce antibody neutralization and acquire usage of mouse ACE2

R Wang, Q Zhang, R Zhang, ZQ Aw, P Chen… - Frontiers in …, 2022 - frontiersin.org
… We next studied the binding activity of these antibodies individually or in combination to the
spike protein of the three Omicron variants expressed on the surface of HEK293T (Figure 2). …

mRNA vaccine-elicited antibodies to SARS-CoV-2 and circulating variants

Z Wang, F Schmidt, Y Weisblum, F Muecksch… - Nature, 2021 - nature.com
… However, combinations of antibodies remained effective against all of the variants we
tested, which confirms the importance of using combinations of antibodies in the clinic (Extended …