SARS-CoV-2 neutralizing antibody structures inform therapeutic strategies

CO Barnes, CA Jette, ME Abernathy, KMA Dam… - Nature, 2020 - nature.com
… Class 3 human NAbs add to the anti-SARS-CoV-2 antibody repertoire and could probably
be effectively used in therapeutic combinations with class 1 or 2 NAbs. However, when using …

Three epitope-distinct human antibodies from RenMab mice neutralize SARS-CoV-2 and cooperatively minimize the escape of mutants

J Nie, J Xie, S Liu, J Wu, C Liu, J Li, Y Liu, M Wang… - Cell Discovery, 2021 - nature.com
… selected in this study, the broad-spectrum neutralization activity of cocktail antibodies is the
Tri-combination, for which the only escape mutant was T478I. The T478I mutation accounted …

SARS-CoV-2 Omicron variants reduce antibody neutralization and acquire usage of mouse ACE2

R Wang, Q Zhang, R Zhang, ZQ Aw, P Chen… - Frontiers in …, 2022 - frontiersin.org
… We next studied the binding activity of these antibodies individually or in combination to the
spike protein of the three Omicron variants expressed on the surface of HEK293T (Figure 2). …

Current status of therapeutic monoclonal antibodies against SARS-CoV-2

S Kumar, A Chandele, A Sharma - PLoS pathogens, 2021 - journals.plos.org
… Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and … and imdevimab) against
SARS-CoV-2 was approved for … against SARS--CoV-2 and its rapidly emerging variants. …

[HTML][HTML] Neutralizing antibodies targeting SARS-CoV-2 spike protein

S Xiaojie, L Yu, Y Guang, Q Min - Stem cell research, 2021 - Elsevier
… COV2-2196 or COV2-2130 (with IC 50 of 15, 107 ng/mL to authentic virus, and 0.7, 1.6 ng/mL
to pseudovirus, respectively) alone or in combination protected mice from SARS-CoV-2 …

Analysis of SARS-CoV-2 antibodies in COVID-19 convalescent blood using a coronavirus antigen microarray

RR De Assis, A Jain, R Nakajima, A Jasinskas… - Nature …, 2021 - nature.com
… In order to rank the individual antigens and combinations of antigens from SARS-CoV-2
for performance in discriminating the positive and negative groups, the receiver operating …

Genetic and structural basis for SARS-CoV-2 variant neutralization by a two-antibody cocktail

J Dong, SJ Zost, AJ Greaney, TN Starr… - Nature …, 2021 - nature.com
… -2 VOCs and demonstrated that the individual antibodies or their combination are
capable of potently neutralizing these emerging variants. Recent work from others has also …

A perspective on potential antibody-dependent enhancement of SARS-CoV-2

AM Arvin, K Fink, MA Schmid, A Cathcart, R Spreafico… - Nature, 2020 - nature.com
… of coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV… , and their potential implications for SARS-CoV-2 infection. At …

Examining protective effects of SARS-CoV-2 neutralizing antibodies after vaccination or monoclonal antibody administration

D Follmann, MP O'Brien, J Fintzi, MP Fay… - Nature …, 2023 - nature.com
SARS CoV-2 is driven entirely by passive immunity with exogenous monoclonal antibodies
30 , … Our analyses are for a specific mAb combination and vaccine, similar analyses for other …

[HTML][HTML] A highly potent antibody effective against SARS-CoV-2 variants of concern

C Fenwick, P Turelli, L Perez, C Pellaton… - Cell reports, 2021 - cell.com
… perspectives either as a prophylactic agent in immunocompromised individuals with poor
response to vaccination or as combination therapy in SARS-CoV-2-infected individuals. …