SARS CoV-2-induced viral sepsis: the role of gut barrier dysfunction

SF Assimakopoulos, G Eleftheriotis, M Lagadinou… - Microorganisms, 2022 - mdpi.com
… Overview of intestinal barrier dysfunction in SARS-CoV-2 infection: SARS-CoV-2 infection
induces a multifactorial disruption of intestinal barrier integrity by negatively affecting all of its …

SARS-CoV-2 causes severe epithelial inflammation and barrier dysfunction

S Deinhardt-Emmer, S Böttcher, C Häring… - Journal of …, 2021 - Am Soc Microbiol
… Our data show that SARS-CoV-2 efficiently infected epithelial … barrier function deteriorated,
allowing the viral particles to overbear. In our study, we demonstrate that although SARS-CoV-…

Role of aging in blood–brain barrier dysfunction and susceptibility to SARS-CoV-2 infection: impacts on neurological symptoms of COVID-19

D Adesse, L Gladulich, L Alvarez-Rosa… - … and Barriers of the CNS, 2022 - Springer
… However, at present, the interactions of SARS-CoV-2 with the NVU and the outcomes of this
… the impact of SARS-CoV-2 on the NVU, the expression profile of SARS-CoV-2 receptors in …

Anti–SARS-CoV-2 antibodies in the CSF, blood-brain barrier dysfunction, and neurological outcome: studies in 8 stuporous and comatose patients

H Alexopoulos, E Magira, K Bitzogli… - Neurology …, 2020 - AAN Enterprises
… respiratory syndrome coronavirus 2 (SARS-CoV-2) in the serum and CSF using a Food
and Drug Administration-approved and independently validated ELISA. Blood-brain barrier (BBB…

Intestinal barrier function in health and disease—any role of SARS-CoV-2?

L Sharma, A Riva - Microorganisms, 2020 - mdpi.com
barrier alterations and indicates areas where therapeutic strategies may ameliorate barrier
dysfunctions… Additionally, it has been shown that SARS coronavirus (SARS-CoV) can impact …

SARS-CoV-2 Spike triggers barrier dysfunction and vascular leak via integrins and TGF-β signaling

SB Biering, FT Gomes de Sousa, LV Tjang… - Nature …, 2022 - nature.com
… Thus, we propose that SARS-CoV-2 can trigger barrier dysfunction through multiple avenues,
including (1) during infection of virus-permissive cells, (2) through shedding of soluble S1 …

[HTML][HTML] … SARS-CoV-2 spike protein subunit S1 induces COVID-19-like acute lung injury in Κ18-hACE2 transgenic mice and barrier dysfunction in human endothelial …

RMLC Biancatelli, PA Solopov… - … of Physiology-Lung …, 2021 - journals.physiology.org
… Cell entry of SARS-CoV-2 occurs via the interaction between … instilled the S1 subunit of
SARS-CoV-2 spike protein (S1SP) … resistance (TER) and barrier function. This is the first …

[HTML][HTML] Intestinal barrier dysfunction as a key driver of severe COVID-19

EP Tsounis, C Triantos, C Konstantakis… - World Journal of …, 2023 - ncbi.nlm.nih.gov
… the deleterious effects of SARS-CoV-2 infection on gut barrier homeostasis. Subsequently,
we discuss the mechanisms that explain how intestinal barrier dysfunction might drive severe …

Interactions of SARS-CoV-2 with the blood–brain barrier

MA Erickson, EM Rhea, RC Knopp… - International Journal of …, 2021 - mdpi.com
… The blood–brain barrier (BBB) is a critical interface that regulates entry of … SARS-CoV-2
interactions with the BBB may contribute to neurological dysfunction associated with coronavirus

HSP90 inhibitors modulate SARS-CoV-2 spike protein subunit 1-induced human pulmonary microvascular endothelial activation and barrier dysfunction

RML Colunga Biancatelli, PA Solopov… - Frontiers in …, 2022 - frontiersin.org
… The pathophysiology of endothelial dysfunction in COVID-19 is not completely understood.
… subunit 1 of the SARS-CoV-2 spike protein (S1SP) in eliciting endothelial barrier dysfunction, …