[HTML][HTML] SARS-CoV-2 spike protein induces cognitive deficit and anxiety-like behavior in mouse via non-cell autonomous hippocampal neuronal death

J Oh, WH Cho, E Barcelon, KH Kim, J Hong, SJ Lee - Scientific reports, 2022 - nature.com
… We explored the possibility that the brain-infiltrating SARS-CoV-2 spike … behavioral study
showed that administration of SARS-CoV-2 spike protein S1 subunit (S1 protein) to mouse

Prenatal SARS-CoV-2 infection results in neurodevelopmental and behavioral outcomes in mice

CL McMahon, EM Hurley, AM Perez, M Estrada… - JCI …, 2024 - Am Soc Clin Investig
… -related behaviors, such as … mice infected in utero with SARS-CoV-2 displayed 234
developmental deficits such as slowed growth and lower weight in adulthood, as well as behavioral

[HTML][HTML] SARS-CoV-2 envelope protein triggers depression-like behaviors and dysosmia via TLR2-mediated neuroinflammation in mice

W Su, J Ju, M Gu, X Wang, S Liu, J Yu, D Mu - Journal of …, 2023 - Springer
… -like behaviors and olfactory disorder in mice (Fig. 7D–G). However, the astrocytes inhibition
by LAA failed to recover the depression-like behaviors and olfactory disorder in mice at our …

[HTML][HTML] Sex-specific microglial activation and SARS-CoV-2 receptor expression induced by chronic unpredictable stress

L Yan, M Jayaram, K Chithanathan… - Frontiers in Cellular …, 2021 - frontiersin.org
… of SARS-CoV2 viral receptors. We observed that female mice showed depressive-like behavior
… of the SARS-CoV-2 receptors in the normal mouse brain using the ISH data in the Allen …

[HTML][HTML] SARS-CoV-2 infection in the mouse olfactory system

Q Ye, J Zhou, Q He, RT Li, G Yang, Y Zhang, SJ Wu… - Cell discovery, 2021 - nature.com
mouse model to demonstrate that SARS-CoV-2 … SARS-CoV-2 infection is the cause of
olfactory dysfunction and anosmia in COVID-19 patients 5,6,22,23 . SARS-CoV-2-infected mice

Mouse models for the study of SARS-CoV-2 infection

AC Knight, SA Montgomery, CA Fletcher… - Comparative …, 2021 - ingentaconnect.com
… -2 infection of the CNS and the potential long-term effects on behavior and neurologic
health… Virus was also detected in the brains of these mice, with the S protein of SARSCoV-2 …

[HTML][HTML] Non-neutralizing antibodies to SARS-Cov-2-related linear epitopes induce psychotic-like behavior in mice

J Xu, H Wei, P You, J Sui, J Xiu, W Zhu… - Frontiers in Molecular …, 2023 - frontiersin.org
coronavirus 2 (SARS-CoV-2) could negatively affect the CNS. After immunizing ApoE-/- mice
… we observed a psychomotor-like behavioral phenotype with defective sensorimotor gating …

[HTML][HTML] Emerging role of kinin B1 receptor in persistent neuroinflammation and neuropsychiatric symptoms in mice following recovery from SARS-CoV-2 infection

S Sriramula, D Theobald, RU Parekh, SM Akula… - Cells, 2023 - mdpi.com
… the behavior of mice that had recovered from a mild SARS-CoV-2 … SARS-CoV-2 infection
enhanced anxiety-related behavior in the zero maze and attenuated exploratory behavior

Shedding light on the toxicity of SARS-CoV-2-derived peptide in non-target COVID-19 organisms: a study involving inbred and outbred mice

TM da Luz, AP da Costa Araújo, FNE Rezende… - Neurotoxicology, 2022 - Elsevier
… Thus, in this study, we aimed to evaluate the behavioral and … mice (male Swiss and
C57Bl/6 J mice, respectively) to PSPD-2002 (peptide fragments of the Spike protein of SARS-CoV-2) …

[PDF][PDF] SARS-CoV-2 Spike protein induces TLR4-mediated long-term cognitive dysfunction recapitulating post-COVID-19 syndrome in mice

FL Fontes-Dantas, GG Fernandes, EG Gutman… - Cell reports, 2023 - cell.com
mice COVID-19 is associated with late cognitive dysfunction.To evaluate whether brain exposure
to SARS-CoV… directly into mouse brains (icv infusion) and followed behavioral changes …