… SARS-CoV-2/spike N501Y virus in BALB/c mice, we 310 successfully isolated a highly virulent
mouse-adapted SARS-CoV-2 … Interestingly, young C57BL/6 mice exhibited reduced 312 …

… have been hardly assessed in mouse models. In this study, we first infected two commonly
used wild-type mouse lines (C57BL/6J and 129S) with mouse-adapted SARS-CoV-2 and …

… mouse model, which is susceptible to SARS-CoV-2 (30). In our pilot study, hACE2 transgenic
mice were intranasally inoculated with SARS-CoV-2 … dose) virus per mouse] and were then …

… Here, we show that two viral models of SARS-CoV-2, a pseudovirus bearing the S protein …
of SARS-CoV-2, readily cross the BBB of the mouse. Indeed, these two models of SARS-CoV-…

… mice and prior results with Mac1 SARS-CoV mutant viruses (18) suggested that ΔMac1 would
induce a strong innate immune response in mice… How do we characterize animal behavior…

… that mice immunized with the peptide corresponding to 674–685 fragment of SARS-Cov-2 …
Mice were examined in behavioral test each week after immunization; the blood (about 100 …

… caused by different routes of SARS-CoV-2 infection rather than the differential viral dose
administered to each mouse, we intranasally infected mice with SARS-CoV-2 at various doses. …

… -2 led to cell–cell fusion and the formation of neuronal syncytium (Figure 4A), corroborating
the specificity of the mouse-adapted virus to this cell type, once this behavior was not …

… description of SARS-CoV-2 infection and replication through the brain. SARS-CoV-2 brain
… signs of glial activation and vascular damage in mice infected with SARS-CoV-2. One or two …

… -making; too much exploitation makes behavior inflexible, while too much … mice had similar
accuracy, they used different explore-exploit strategies during the task. Notably, female mice …