Microgliosis and neuronal proteinopathy in brain persist beyond viral clearance in SARS-CoV-2 hamster model

C Käufer, CS Schreiber, AS Hartke, I Denden… - …, 2022 - thelancet.com
… Here we determined whether intranasal SARS-CoV-2 infection in male and female syrian
golden hamsters results in persistent brain pathology. Brains 3 (symptomatic) or 14 days (viral …

A murine model of post-acute neurological sequelae following SARS-CoV-2 variant infection

A Singh, A Adam, Aditi, BH Peng, X Yu, J Zou… - Frontiers in …, 2024 - frontiersin.org
… tract or use of the mouse-adapted SARS-CoV-2 (SARS-CoV-2 MA … mouse ACE2 for entry
into cells in immunocompetent mice, … Our longitudinal behavior studies indicate development of …

Full efficacy and long-term immunogenicity induced by the SARS-CoV-2 vaccine candidate MVA-CoV2-S in mice

A Lázaro-Frías, P Pérez, C Zamora… - Npj Vaccines, 2022 - nature.com
SARS-CoV-2 spike (S) protein protected K18-hACE2 transgenic mice from a lethal dose of
SARS-CoV-… Similar SARS-CoV-2-specific antibody responses were observed at prechallenge …

Microglia do not restrict SARS-CoV-2 replication following infection of the central nervous system of K18-human ACE2 transgenic mice

GM Olivarria, Y Cheng, S Furman, C Pachow… - Journal of …, 2022 - Am Soc Microbiol
… -hACE2 mice, initially used as a mouse model of SARS-CoV-1… Intranasal inoculation of
SARS-CoV-2 in K18-hACE2 mice … brains of SARS-CoV-2 infected hACE2 transgenic mice has …

Age-associated SARS-CoV-2 breakthrough infection and changes in immune response in a mouse model

Y Chen, C Li, F Liu, Z Ye, W Song… - Emerging Microbes & …, 2022 - Taylor & Francis
… compared aged mice and young mice on SARS-CoV-2 … physiological mouse model challenged
by the wild-type SARS-CoV-… in aged mice compared with young mice upon SARS-CoV-2 …

Evolution of ACE2-independent SARS-CoV-2 infection and mouse adaption after passage in cells expressing human and mouse ACE2

K Yan, T Dumenil, B Tang, TT Le, CR Bishop… - Virus …, 2022 - academic.oup.com
… unable to use mouse ACE2 (mACE2). Herein we describe the emergence of a SARS-CoV-2 …
To characterize the in vivo behavior of SARS-CoV-2 that evolved mACE2-binding capacity …

SARS-CoV-2 infection causes transient olfactory dysfunction in mice

Q Ye, J Zhou, G Yang, RT Li, Q He, Y Zhang, SJ Wu… - BioRxiv, 2020 - biorxiv.org
… an established mouse model to demonstrate that SARS-CoV-2 … evidence support the
hypothesis that SARS-CoV-2 infection as … The SARS-CoV-2 infected mice exhibited damaged OE, …

Mitochondrial antioxidants abate SARS-COV-2 pathology in mice

JW Guarnieri, T Lie, YES Albrecht, P Hewin… - Proceedings of the …, 2024 - pnas.org
… we challenged mice expressing human angiotensin-converting enzyme 2 (ACE2) with
SARS-CoV-… These data demonstrate that SARS-CoV-2 pathology can be mitigated by catalytically …

Analysis of SARS-CoV-2 infection dynamic in vivo using reporter-expressing viruses

C Ye, K Chiem, JG Park, JA Silvas… - Proceedings of the …, 2021 - National Acad Sciences
… from SARS-CoV-2−infected mice, it did not allow us to track viral infection in the entire mouse
… Emotions coordinate our behavior and physiological states during survival-salient events …

SARSCoV‐2‐related bat virus behavior in human‐relevant models sheds light on the origin of COVID‐19

S Temmam, X Montagutelli, C Herate, F Donati… - EMBO …, 2023 - embopress.org
… Notably, viral load in mouse lungs was around 2 logs lower than upon SARSCoV‐2
infection, suggesting that transmission through the respiratory route was less efficient for BANAL‐…