[HTML][HTML] What SARS-CoV-2 does to our brains

T Aschman, R Mothes, FL Heppner, H Radbruch - Immunity, 2022 - cell.com
… As indisputable evidence of intact and replicating SARS-CoV-… neurocognitive symptoms
associated with SARS-CoV-2 infection… on the molecular pathways involved in sickness behavior. …

Recovery of anosmia in hamsters infected with SARS-CoV-2 is correlated with repair of the olfactory epithelium

RA Reyna, M Kishimoto-Urata, S Urata, T Makishima… - Scientific reports, 2022 - nature.com
… In this study, we developed a behavioral test of anosmia in SARS-CoV-2-infected hamsters.
… olfactory pathway in mice. V. Long-term effect of intranasal ZnSO 4 irrigation on behavior, …

Role of spike in the pathogenic and antigenic behavior of SARS-CoV-2 BA. 1 Omicron

DY Chen, D Kenney, CV Chin, AH Tavares, N Khan… - BioRxiv, 2022 - biorxiv.org
… To examine if Omi-S exhibits higher in vivo fitness compared with Omicron, we investigated
the infection outcome of Omi-S relative to WT SARS-CoV-2 and Omicron in K18-hACE2 mice

[HTML][HTML] Fetal brain vulnerability to SARS-CoV-2 infection

CL McMahon, J Castro, J Silvas, AM Perez… - Brain, Behavior, and …, 2023 - Elsevier
… Whether or not SARS-CoV-2 can cross from mother to fetus during a prenatal … SARS-CoV-2
and the consequences of infection on the developing brain using human ACE2 knock-in mice

The Delta SARS-CoV-2 variant of concern induces distinct pathogenic patterns of respiratory disease in K18-hACE2 transgenic mice compared to the ancestral strain …

X Liu, H Mostafavi, WH Ng, JR Freitas, NJC King… - MBio, 2022 - Am Soc Microbiol
… brain will lead to any long-term consequence in mouse behavior. The brain tissue damage
observed in this study may help to establish a disease model for future studies. Leukocyte …

A single dose of self-transcribing and replicating RNA-based SARS-CoV-2 vaccine produces protective adaptive immunity in mice

R De Alwis, ES Gan, S Chen, YS Leong, HC Tan… - Molecular Therapy, 2021 - cell.com
… and prolongs SARS-CoV-2 spike glycoprotein expression. A single prime vaccination in mice
led … transgenic mice from both mortality and even measurable infection following wild-type …

Development of transgenic models susceptible and resistant to SARS-CoV-2 infection in FVB background mice

SM Seo, JH Son, JH Lee, NW Kim, ES Yoo, AR Kang… - PloS one, 2022 - journals.plos.org
… -hACE2 mice are resistant to SARS-CoV-2. … mouse is suitable for highly susceptible model
of SARS-CoV-2, and CAG-hACE2 mouse is suitable for mild susceptible model of SARS-CoV-…

Development of a Mouse-Adapted Reporter SARS-CoV-2 as a Tool for Two-Photon In Vivo Imaging

H Ueki, M Kiso, Y Furusawa, S Iida, S Yamayoshi… - Viruses, 2024 - mdpi.com
mice and emits sufficient light intensity for two-photon in vivo imaging. Here, we generated a
mouse-adapted strain of SARS-CoV… in the lungs of C57BL/6 mice, causing fatal pneumonia. …

Defining the Syrian hamster as a highly susceptible preclinical model for SARS-CoV-2 infection

K Rosenke, K Meade-White, M Letko… - Emerging microbes & …, 2020 - Taylor & Francis
mouse ACE2 promoter [Citation16, Citation24–26]. All of these mice are susceptible to
SARS-CoV-2 … SARS-CoV-2 adaptation to mice has also been attempted through either serial …

[HTML][HTML] The SARS-CoV-2 Spike protein induces long-term transcriptional perturbations of mitochondrial metabolic genes, causes cardiac fibrosis, and reduces …

X Cao, V Nguyen, J Tsai, C Gao, Y Tian, Y Zhang… - Molecular …, 2023 - Elsevier
… A Spike protein-pseudotyped (Spp) virus with the proper surface tropism of SARS-CoV-2
was developed for viral entry assay in vitro and administration into high fat diet (HFD)-fed mice. …