How does SARS-CoV-2 affect the central nervous system? A working hypothesis

F Panariello, L Cellini, M Speciani, D De Ronchi… - Frontiers in …, 2020 - frontiersin.org
… , transgenic mice upregulating ACE2 exhibit behavior compatible … behavior, suggesting that
the Ang-(1-7)/MasR axis is involved in the modulation of anxiety levels and related behaviors

The SARS-CoV-2 main protease Mpro causes microvascular brain pathology by cleaving NEMO in brain endothelial cells

J Wenzel, J Lampe, H Müller-Fielitz, R Schuster… - Nature …, 2021 - nature.com
… In brains of SARS-CoV-2-infected patients, as well as mouse and hamster models, we
found an increase in empty vascular basement membrane tubes, so-called string vessels, …

SARS-CoV-2 Infects Endothelial Cells In Vivo and In Vitro

F Liu, K Han, R Blair, K Kenst, Z Qin, B Upcin… - Frontiers in cellular …, 2021 - frontiersin.org
… Further, we showed that SARS-CoV-2 directly infects mature mouse aortic endothelial cells
(… -2 endothelial infection since a) it enables the study of endothelial cell behavior in its natural …

A neonatal mouse model characterizes transmissibility of SARS-CoV-2 variants and reveals a role for ORF8

BA Rodriguez-Rodriguez, GO Ciabattoni… - Nature …, 2023 - nature.com
mice do not robustly transmit SARS-CoV-2. Here we establish a model based on neonatal
mice that allows for transmission of clinical SARS-CoV-2 … model features behavioral situations …

BSL2-compliant lethal mouse model of SARS-CoV-2 and variants of concern to evaluate therapeutics targeting the Spike protein

M Manangeeswaran, DDC Ireland… - Frontiers in …, 2022 - frontiersin.org
… was replaced by the SARS-CoV-2 spike … mice (hACE2tg) leads to productive infection of
the lungs and brains. Although disease progression was faster in SARS-CoV-2 infected mice, …

… single dose of an MVA vaccine expressing a prefusion-stabilized SARS-CoV-2 spike protein neutralizes variants of concern and protects mice from a lethal SARS-CoV …

P Perez, A Lazaro-Frias, C Zamora… - Frontiers in …, 2022 - frontiersin.org
… , two doses of MVA-CoV2-S or MVA-CoV2-S(3P) induced similar levels of SARS-CoV-2-…
hACE2 mice from morbidity and mortality caused by SARS-CoV-2 infection, reducing SARS-CoV

Structural basis for mouse receptor recognition by bat SARS2-like coronaviruses

W Zhang, K Shi, FC Hsueh, A Mendoza, G Ye… - Proceedings of the …, 2024 - pnas.org
… of SARS-CoV-2 spike, we examined the crystal structures of the spike receptor-binding
domains (RBDs) of BANAL-236 and RaTG13 each complexed with mouse … our behavior and …

SARS-CoV-2 spike protein intensifies cerebrovascular complications in diabetic hACE2 mice through RAAS and TLR signaling activation

FN Burnett, M Coucha, DR Bolduc… - International Journal of …, 2023 - mdpi.com
… to SARS-CoV-2 neurological manifestations. The molecular mechanisms of SARS-CoV-2-…
We hypothesize that SARS-CoV-2 exacerbates diabetes-induced cerebrovascular oxidative …

[HTML][HTML] Mild respiratory SARS-CoV-2 infection can cause multi-lineage cellular dysregulation and myelin loss in the brain

A Fernández-Castañeda, P Lu, AC Geraghty, E Song… - BioRxiv, 2022 - ncbi.nlm.nih.gov
behavior; the challenges of working with a biosafetly level-3 mouse model limited the
feasibility of further behavioral … the mouse hippocampus following mild respiratory SARS-CoV-2 …

Osteoclast-mediated bone loss observed in a COVID-19 mouse model

OD Awosanya, CE Dalloul, RJ Blosser, UC Dadwal… - Bone, 2022 - Elsevier
… -infected” mice exhibited very similar health and behavior traits … a WT mouse infected with 1
× 10 3 PFU of SARS-CoV-2, … a TG mouse infected with 1 × 10 4 PFU of SARS-CoV-2 that had …