… To determine the effects of SARS-CoV-2 ORFs on caspase-1-mediated IL-1β activation, …
with vectors expressing caspase-1 and pro-IL-1β, plus the expression vectors for SARS-CoV-2 …

… Here we report that SARS-CoV-2 infection activates caspase-… observed in the lung sections
of SARS-CoV-2-infected HFH4-… the pro-IL-1β at the same site with caspase-1. We found that …

… Next, we measured caspase-1 activation, a downstream … reduced SARS-CoV-2-mediated
caspase-1 activation and cell … caspase-1 activation and pyroptosis in SARS-CoV-2 infection. …

… Using genetic and pharmacological inhibition, we show that the induction of mature IL-1β
is through a non-classical pathway dependent on caspase-1, caspase-8, the NLRP3 …

… caspase-1 by these four compounds was analyzed using computational methods. Our aim
was to see if the inhibition of caspase-1, … involved in response to the SARS-CoV-2 virus attack. …

… and was induced by SARS-CoV-1 [1]. SARS-CoV-2 is a new type of coronavirus that can
affect … NSP1 and NSP13 inhibited caspase-1-mediated IL-1β activation in THP-1 cells. These …

… immune perturbations 29 Building on our previous findings, we sought to expand our
analysis to investigate caspase-1 activity in SARS-CoV-2 infection, as well as the role of other …

… In our experimental condition, SARS-CoV-2 SP incubation … enhanced by the NLRP3/Caspase-1
pathway activation. These … These consequences of NLRP3/Caspase-1 inflammasome …

… by activated caspases, mainly Caspase 1 or 11 (Caspase 4/5 … the so far elucidated ways of
SARS-CoV-2 induced NLRP3 … the fact that Caspase 1 is crucial for IL-1 release, Caspase 1 …

… inflammasome complex with consequent cleavage of pro-caspase-1 into active caspase-1. …
In a mouse model of SARS-CoV-1, delayed type 1 IFN signaling was accompanied by the …