SARS-CoV-2 human T cell epitopes: Adaptive immune response against COVID-19

A Grifoni, J Sidney, R Vita, B Peters, S Crotty… - Cell host & …, 2021 - cell.com
… between number of epitopes defined and … SARS-CoV-2 human CD4 and CD8 T cell epitope
data compiled from these studies, identifying 1,400 different reported SARS-CoV-2 epitopes

SARS-CoV-2 genome-wide T cell epitope mapping reveals immunodominance and substantial CD8+ T cell activation in COVID-19 patients

SK Saini, DS Hersby, T Tamhane, HR Povlsen… - Science …, 2021 - science.org
… of CD8 + T cell–mediated immune response to SARS-CoV-2 … potential T cell epitopes
within the complete SARS-CoV-2 … T cell recognition, immunodominance, breadth of the T cell

Identification of SARS-CoV-2 nucleocapsid and spike T-cell epitopes for assessing T-cell immunity

E Lee, K Sandgren, G Duette, VV Stylianou… - Journal of …, 2021 - Am Soc Microbiol
… to SARS coronavirus and other organisms. We only used the protein regions that were …
to SARS coronavirus to define T-cell epitopes. Identifying highly networked epitopes within …

SARS-CoV-2 mutations in MHC-I-restricted epitopes evade CD8+ T cell responses

…, R Torralba-Gombau, D Trapin, T Penz… - Science …, 2021 - science.org
… MHC-I-restricted CD8 + T cell epitopes after deep sequencing of 747 SARS-CoV-2 virus
isolates. Mutant peptides exhibited diminished or abrogated MHC-I binding in a cell-free in vitro …

[HTML][HTML] SARS-CoV-2 epitopes are recognized by a public and diverse repertoire of human T cell receptors

AS Shomuradova, MS Vagida, SA Sheetikov… - Immunity, 2020 - cell.com
T cell response to SARS-CoV-2 epitopes, revealing T cell … Bulk CD4 + and CD8 + T cell
responses to the spike protein were … T cell epitopes have been identified for the SARS-CoV S …

T cell epitopes in SARS-CoV-2 proteins are substantially conserved in the Omicron variant

SJ Choi, DU Kim, JY Noh, S Kim, SH Park… - Cellular & molecular …, 2022 - nature.com
epitopes by a meta-analysis of CD8 + T cell epitope data from 18 studies with 852 COVID-19
convalescents [6], and all 19 CD8 + T cell epitopes were … CD4 + T cell epitopes that were …

Prevalent and immunodominant CD8 T cell epitopes are conserved in SARS-CoV-2 variants

S Meyer, I Blaas, RC Bollineni, M Delic-Sarac, TT Tran… - Cell reports, 2023 - cell.com
… immunity have been hampered by uncertain estimates of epitope prevalence. Here, we
map and quantify CD8 T cell responses to SARS-CoV-2-specific minimal epitopes in blood …

Profiling CD8+ T cell epitopes of COVID-19 convalescents reveals reduced cellular immune responses to SARS-CoV-2 variants

H Zhang, S Deng, L Ren, P Zheng, X Hu, T Jin, X Tan - Cell reports, 2021 - cell.com
… These studies have revealed a number of CD8 + T cell epitopes that are conserved between
SARS-CoV-2 and other human coronaviruses that cause the common cold, which provided …

Comprehensive analysis of T cell immunodominance and immunoprevalence of SARS-CoV-2 epitopes in COVID-19 cases

A Tarke, J Sidney, CK Kidd, JM Dan, SI Ramirez… - Cell Reports …, 2021 - cell.com
SARS-CoV-2 antigens and precisely measure virus-specific CD4 + and CD8 + T cells, we
study epitope-specific T cell … but the exact T cell epitopes and immunodominant antigen …

Bioinformatic prediction of potential T cell epitopes for SARS-Cov-2

K Kiyotani, Y Toyoshima, K Nemoto… - Journal of human …, 2020 - nature.com
epitopes were significantly enriched. By comparing the sequences of these predicted T cell
epitopes to … HLA-class II epitopes that have high homologies to SARS-CoV. To further select …