[PDF][PDF] Imbalanced host response to SARS-CoV-2 drives development of COVID-19

D Blanco-Melo, BE Nilsson-Payant, WC Liu, S Uhl… - Cell, 2020 - cell.com
… of a cytokine response marked by CCL8 and CXCL9, consistent with what was observed
in cell culture. By day 7, despite waning levels of virus, the cytokine response continued to …

[HTML][HTML] Distinct systemic and mucosal immune responses during acute SARS-CoV-2 infection

N Smith, P Goncalves, B Charbit, L Grzelak… - Nature …, 2021 - nature.com
… and local immune responses during active SARS-CoV-2 infection in a well-characterized
COVID-19 cohort. We measured host antibody and cytokine responses, determined viral load …

Cytokine storm and leukocyte changes in mild versus severe SARS-CoV-2 infection: Review of 3939 COVID-19 patients in China and emerging pathogenesis and …

J Wang, M Jiang, X Chen… - Journal of Leucocyte …, 2020 - academic.oup.com
… For example, a lack of a negative feedback mechanism by IL-10 and IL-4 would be expected
to increase the severity of cytokine responses toward a pathogenic CRS or cytokine storm. …

The roles of critical pro‐inflammatory cytokines in the drive of cytokine storm during SARSCoV‐2 infection

MS Qudus, M Tian, S Sirajuddin, S Liu… - Journal of Medical …, 2023 - Wiley Online Library
… In addition to asymptomatic courses, SARS-CoV-2 patients brought … cytokine and chemokine
secretions resulting from host immunological responses to SARS-CoV-2 infection, cytokine

[HTML][HTML] Immune response in SARS-CoV-2 infection: the role of interferons type I and type III

CP Sousa, C Brites - Brazilian Journal of Infectious Diseases, 2020 - SciELO Brasil
… Quantitation analysis and prognostic implication of SARS coronavirus RNA in the plasma
and serum of patients with … Interferon and cytokine responses to SARS-coronavirus infection. …

T cell responses to whole SARS coronavirus in humans

CK Li, H Wu, H Yan, S Ma, L Wang… - The Journal of …, 2008 - journals.aai.org
… and an acute cohort to study acute infection through serum cytokine responses. This study
was approved by the ethical research committees of the Medical School of Oxford University (…

[HTML][HTML] Could SARS-CoV-2-induced hyperinflammation magnify the severity of coronavirus disease (CoViD-19) leading to acute respiratory distress syndrome?

ASS Girija, EM Shankar, M Larsson - Frontiers in immunology, 2020 - frontiersin.org
Cytokine storm likely could dampen innate and adaptive immune responses against
SARS-CoV… hypercytokinemia resulting from cytokine release largely by SARS-CoV-infected ACE2-…

T‐cell responses and therapies against SARSCoV‐2 infection

SM Toor, R Saleh, V Sasidharan Nair, RZ Taha… - …, 2021 - Wiley Online Library
cytokine release syndrome and severe systemic inflammatory responses in patients with
advanced stages of SARS-CoV-… and/or inadequate Th1 responses in these patients. It was also …

[HTML][HTML] TLR2 senses the SARS-CoV-2 envelope protein to produce inflammatory cytokines

M Zheng, R Karki, EP Williams, D Yang… - Nature …, 2021 - nature.com
… Myd88 is important for proinflammatory cytokine production during MHV and SARS-CoV-1 …
-β) plays a role in SARS-CoV-2-induced inflammatory responses and pathogenesis, we first …

… Responses to Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) Infection in Senescent BALB/c Mice: CD4+ T Cells Are Important in Control of SARS …

J Chen, YF Lau, EW Lamirande, CD Paddock… - Journal of …, 2010 - Am Soc Microbiol
… -induced pneumonitis, we measured the protein levels of cytokines and chemokines in
lung homogenates (Fig. 1A and B). We describe events in the first 1 to 5 days pi as early and …