… This review compares the characters of cytokine storms and immune responses caused by
… coronavirus (SARS-CoV), Middle East respiratory syndrome-coronavirus (MERS-CoV), and …

… Here, we summarize the pharmacologic therapies that have the potential to suppress
SARS-CoV-2-induced cytokine storms (Table 1). The medications that target the performance of …

… that SARS-CoV-2 coding protein open reading frame 8 (ORF8) acted as a contributing factor
to cytokine storm … the pathogenesis of cytokine storm caused by SARS-CoV-2 and provide a …

… To explore whether the ORF3a protein of SARS-CoV-2 could trigger cytokine storms, we
treated macrophages with ORF3a lentivirus. The ORF3a protein not only stimulated …

… Rhein, an active metabolite of diacerein (anthraquinone derivative), is known to inhibit
cytokine storm and viral replication as well as inhibits SARS-CoV-2 spike protein and ACE2 …

… SARS-CoV-2 have a high cytokine profile similar to CS. Studies have reported the level of
inflammatory factors in patients with SARSCoV-2 during CS, cytokine … IL-6 in severe SARSCoV…

… Available evidence indicate that the so called “cytokine storm” an … in the cytokine storm
related to SARS-CoV-2 infection. Basic and clinical evidences obtained from previous SARS and …

… cytokine storm. Recent attention has centered around the possibility of therapeutic intervention
with anti-IL-6 … for severe SARS-CoV-2 infection in terms of dampening the downstream …

… inflammasome hyperactivation in the pathogenesis of SARS-CoV-2 caused multi organ …
to cytokine storm and cell death by pyroptosis (Fig. 1). First, it is possible that the SARS-CoV-2 …

… SARS-CoV-2 stimulates the secretion of IL-6 and TNF, a pro-inflammatory complex that can
lead to cytokine storm … In SARS-CoV-2 septic shock, severe metabolic cellular abnormalities …