[HTML][HTML] Identification of human single-domain antibodies against SARS-CoV-2

Y Wu, C Li, S Xia, X Tian, Y Kong, Z Wang, C Gu… - Cell host & …, 2020 - cell.com
… Panning this library against SARS-CoV-2 RBD and S1 subunit identified fully human
single-domain antibodies targeting five distinct epitopes on SARS-CoV-2 RBD with subnanomolar …

Anti-SARS-CoV-2 receptor-binding domain antibody evolution after mRNA vaccination

A Cho, F Muecksch, D Schaefer-Babajew, Z Wang… - Nature, 2021 - nature.com
… Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) … potent antibodies that
are resistant to mutations found in variants of concern 1 . As a result, vaccination of coronavirus

Slaying SARS-CoV-2 one (single-domain) antibody at a time

TF Czajka, DJ Vance, NJ Mantis - Trends in microbiology, 2021 - cell.com
domain (RBD) of the SARS-CoV-2 Spike protein. We discuss the possible applications of
these antibodies in … The highly contagious novel coronavirus, SARS-CoV-2, continues to infect …

Humanized single domain antibodies neutralize SARS-CoV-2 by targeting the spike receptor binding domain

X Chi, X Liu, C Wang, X Zhang, X Li, J Hou… - Nature …, 2020 - nature.com
… Neutralizing antibodies provide efficient blockade for viral … SARS-CoV-2 spike receptor-binding
domain (RBD) as a bait, we generate a panel of humanized single domain antibodies (…

The role of single-domain antibodies (or nanobodies) in SARS-CoV-2 neutralization

A Zebardast, P Hosseini, A Hasanzadeh… - Molecular Biology …, 2022 - Springer
… to their human heavy-chain variable domain counterparts [39, 40]. The first adult medication
developed based on the single-domain antibody (sdAb) was approved in November 2018 …

Receptor-binding domain-specific human neutralizing monoclonal antibodies against SARS-CoV and SARS-CoV-2

F Yu, R Xiang, X Deng, L Wang, Z Yu, S Tian… - … and Targeted Therapy, 2020 - nature.com
domain antibody H11 that specifically binds to SARS-CoV-2 RBD was identified by screening
a naive llama phage display antibody … that have higher affinity for SARS-CoV-2 RBD were …

Single-domain antibodies efficiently neutralize SARS-CoV-2 variants of concern

IA Favorskaya, DV Shcheblyakov… - Frontiers in …, 2022 - frontiersin.org
… To identify SARS-CoV-2 neutralizing single-domain antibodies we immunized one Bactrian
camel with SARS-CoV-2 RBD. The recombinant RBD protein was previously produced in …

Single-domain antibodies for the detection of SARS-CoV-2 nucleocapsid protein

GP Anderson, JL Liu, TJ Esparza, BT Voelker… - Analytical …, 2021 - ACS Publications
domains derived from camelid heavy-chain antibodies known as single-domain antibodies
(sdAbs) directed against the SARS-CoV-2 … using a recombinant SARS-CoV-2 nucleocapsid …

Discovery and multimerization of cross-reactive single-domain antibodies against SARS-like viruses to enhance potency and address emerging SARS-CoV-2 variants

SA Hollingsworth, CL Noland, K Vroom, A Saha… - Scientific Reports, 2023 - nature.com
… , we have identified single domain antibodies (VHHs) … (SARS-CoV, SARS-CoV-2, and
MERS). Importantly, a number of these antibodies show sub-nanomolar potency towards all SARS-…

Structural basis for SARS-CoV-2 nucleocapsid protein recognition by single-domain antibodies

Q Ye, S Lu, KD Corbett - Frontiers in immunology, 2021 - frontiersin.org
… -domain antibodies bound to defined domains of the SARS-CoV-2 N protein. Two sdAbs
bind the N-terminal RNA binding domain, and one binds the C-terminal dimerization domain. …