Viral clearance, pharmacokinetics and tolerability of ensovibep in patients with mild to moderate COVID‐19: A phase 2a, open‐label, single‐dose escalation study

MLM Prins, JL van der Plas… - British Journal of …, 2023 - Wiley Online Library
… had a dose-escalation design, meaning that the 600 mg dose … data of the 225-mg dose.
Patients remained in the clinical … anti-SARS-CoV-2 neutralizing activity and anti-SARS-CoV-2 …

Progressive increase in virulence of novel SARS-CoV-2 variants in Ontario, Canada

DN Fisman, AR Tuite - MedRxiv, 2021 - medrxiv.org
… of first and second doses of approved SARS-CoV-2 vaccines (… days after receipt of the
second dose; partially vaccinated if the … escalation in risk to public health during the SARS-CoV-2 …

Safety, tolerability, pharmacokinetic characteristics, and immunogenicity of MW33: a Phase 1 clinical study of the SARS-CoV-2 RBD-targeting monoclonal antibody

X Meng, P Wang, Y Xiong, Y Wu, X Lin… - Emerging Microbes & …, 2021 - Taylor & Francis
… We conducted a randomized, double-blind, placebo-controlled, single-dose, dose-escalation
Phase 1 study to evaluate the safety, tolerability, pharmacokinetics (PK), and …

First-in-Human Study to Evaluate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of a Rapidly Developed SARS-CoV-2 Therapeutic Antibody, AOD01 …

VS Prativadibhayankaram, LSU Lee, D Lye… - Infectious Diseases and …, 2022 - Springer
SARS-CoV-2 was recorded until day 29 with single doses from 2 to 20 mg/kg and until day
43 with two doses … rhesus macaque SARS-CoV-2 models, AOD01, at a single dose of 20 mg/…

Safety and immunogenicity of a measles-vectored SARS-CoV-2 vaccine candidate, V591/TMV-083, in healthy adults: results of a randomized, placebo-controlled …

O Launay, C Artaud, M Lachâtre, M Ait-Ahmed… - …, 2022 - thelancet.com
… We performed a randomized, placebo-controlled Phase I trial with an unblinded dose
escalation and a double-blind treatment phase at 2 sites in France and Belgium to evaluate the …

Immunogenicity and safety of a 3-dose regimen of a SARS-CoV-2 inactivated vaccine in adults: A randomized, double-blind, placebo-controlled phase 2 trial

J Liu, B Huang, G Li, X Chang, Y Liu… - The Journal of …, 2022 - academic.oup.com
… to receive 3 doses of 5 μg or 10 μg of a SARS-CoV-2 inactivated vaccine, or placebo separated
by 28 days. Adverse events (AEs) were recorded through day 28 after each dosing. Live …

Safety, tolerability, and immunogenicity of an inactivated SARS-CoV-2 vaccine (CoronaVac) in healthy adults aged 60 years and older: a randomised, double-blind …

Z Wu, Y Hu, M Xu, Z Chen, W Yang, Z Jiang… - The Lancet Infectious …, 2021 - thelancet.com
doses (3 μg and 6 μg) in a dose-escalation study with a two-… to live SARS-CoV-2 at day 28
after the second dose. … titre (GMT) of neutralising antibodies to live SARS-CoV-2, as well as …

Multifaceted highly targeted sequential multidrug treatment of early ambulatory high-risk SARS-CoV-2 infection (COVID-19)

PA McCullough, PE Alexander… - Reviews in …, 2020 - scholarlycommons.henryford.com
… , patients endure escalating symptoms and without … dosage for bamlanivimab is a single
IV infusion of 700 mg administered as soon as possible after positive viral test for SARS-CoV-2 …

Single-dose replicating poxvirus vector-based RBD vaccine drives robust humoral and T cell immune response against SARS-CoV-2 infection

S Boulton, J Poutou, NT Martin, T Azad, R Singaravelu… - Molecular Therapy, 2022 - cell.com
… We evaluate the effects of dose escalation and … Our vaccine induces high levels of SARS-CoV-2
neutralizing … immunity against SARS-CoV-2 variants after only a single dose. Together, …

Immunogenicity of clinically relevant SARS-CoV-2 vaccines in nonhuman primates and humans

PJ Klasse, DF Nixon, JP Moore - Science advances, 2021 - science.org
… Multiple vaccines to prevent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …
The animals were challenged with SARS-CoV-2 on day 28 (one-dose group) and day 56 (…