DL McKee, A Sternberg, U Stange, S Laufer… - Pharmacological …, 2020 - Elsevier
… There exists a number of candidatedrugs that may inhibit infection with and replication of SARS-CoV-2. Such drugs comprise inhibitors of TMPRSS2 serine protease and inhibitors of …
W Dai, B Zhang, XM Jiang, H Su, J Li, Y Zhao, X Xie… - Science, 2020 - science.org
… that this compound is a promising drugcandidate. … The x-ray crystal structures of SARS-CoV-2 M pro in complex with … suggests that these compounds are promising drugcandidates. …
… SARS-CoV-2 being a new virus with unusually high mortality, there has been a need to get medicines in an emergency, and the drug … attempt to discover the drugs interacting with RAS …
… have virtually screened FDA approved drugs, drugcandidates and natural compounds. The … The known drugs which were identified as potential inhibitors of NSP16 from SARS-CoV-2 …
… We aim to identify repurposable drugcandidates (green drugs) targeting these key host modulators to interfere with virus replication and disease progression following infection. …
R Yoshino, N Yasuo, M Sekijima - Scientific reports, 2020 - nature.com
… targeting SARS-CoV-2 M pro . However, the mechanism of action of SARS-CoV-2 M pro at … key interactions between SARS-CoV-2 M pro and three drugcandidates by performing …
… of anti-SARS-CoV-2 nanobody drugcandidates, Nanosota-1. … SARS-CoV-2 RBD, the Nanosota-1 series bound potently to the SARS-CoV-2 RBD and were effective at inhibiting SARS-…
M Tsuji - FEBS open bio, 2020 - Wiley Online Library
… library on the basis of drug repositioning. The drugcandidates presented in this study could be further examined for their anti-SARS-CoV-2 activities, together with those of earlier …