Identification of antiviral drug candidates against SARS-CoV-2 from FDA-approved drugs

S Jeon, M Ko, J Lee, I Choi, SY Byun… - Antimicrobial agents …, 2020 - Am Soc Microbiol
… screened 48 FDA-approved drugs based on our SARS-CoV screening, and our screening
campaign revealed 24 potential antiviral drug candidates against SARS-CoV-2. Our findings …

Antivirals against coronaviruses: candidate drugs for SARS-CoV-2 treatment?

IA Santos, VR Grosche, FRG Bergamini… - Frontiers in …, 2020 - frontiersin.org
… severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) … these compounds as
potential SARS-CoV-2 drug candidates. … compounds as potential SARS-CoV-2 drug candidates. …

Candidate drugs against SARS-CoV-2 and COVID-19

DL McKee, A Sternberg, U Stange, S Laufer… - Pharmacological …, 2020 - Elsevier
… There exists a number of candidate drugs that may inhibit infection with and replication of
SARS-CoV-2. Such drugs comprise inhibitors of TMPRSS2 serine protease and inhibitors of …

Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease

W Dai, B Zhang, XM Jiang, H Su, J Li, Y Zhao, X Xie… - Science, 2020 - science.org
… that this compound is a promising drug candidate. … The x-ray crystal structures of SARS-CoV-2
M pro in complex with … suggests that these compounds are promising drug candidates. …

[HTML][HTML] Current targets and drug candidates for prevention and treatment of SARS-CoV-2 (COVID-19) infection

RK Goyal, J Majeed, R Tonk, M Dhobi… - Reviews in …, 2020 - imrpress.com
SARS-CoV-2 being a new virus with unusually high mortality, there has been a need to get
medicines in an emergency, and the drug … attempt to discover the drugs interacting with RAS …

Identification of promising drug candidates against NSP16 of SARS-CoV-2 through computational drug repurposing study

V Vijayan, P Pant, N Vikram, P Kaur… - Journal of …, 2021 - Taylor & Francis
… have virtually screened FDA approved drugs, drug candidates and natural compounds.
The … The known drugs which were identified as potential inhibitors of NSP16 from SARS-CoV-2 …

Exploring the SARS-CoV-2 virus-host-drug interactome for drug repurposing

S Sadegh, J Matschinske, DB Blumenthal… - Nature …, 2020 - nature.com
… We aim to identify repurposable drug candidates (green drugs) targeting these key host
modulators to interfere with virus replication and disease progression following infection. …

Identification of key interactions between SARS-CoV-2 main protease and inhibitor drug candidates

R Yoshino, N Yasuo, M Sekijima - Scientific reports, 2020 - nature.com
… targeting SARS-CoV-2 M pro . However, the mechanism of action of SARS-CoV-2 M pro
at … key interactions between SARS-CoV-2 M pro and three drug candidates by performing …

The development of Nanosota-1 as anti-SARS-CoV-2 nanobody drug candidates

G Ye, J Gallant, J Zheng, C Massey, K Shi, W Tai… - Elife, 2021 - elifesciences.org
… of anti-SARS-CoV-2 nanobody drug candidates, Nanosota-1. … SARS-CoV-2 RBD, the
Nanosota-1 series bound potently to the SARS-CoV-2 RBD and were effective at inhibiting SARS-…

Potential anti‐SARSCoV‐2 drug candidates identified through virtual screening of the ChEMBL database for compounds that target the main coronavirus protease

M Tsuji - FEBS open bio, 2020 - Wiley Online Library
… library on the basis of drug repositioning. The drug candidates presented in this study
could be further examined for their anti-SARS-CoV-2 activities, together with those of earlier …