… that drug resistance might evolve to evade nirmatrelvir inhibition. Studying drug resistance
is also a critical component in antiviral drug … in studying the drug resistance mechanism of …

… governing mechanisms of SARS-CoV-2 inactivation. We then finally present the current
global status of antiviral drug resistance, and future scenarios of antiviral drug resistance both in …

… SARS-CoV-2 viruses generated from reverse genetics, we confirmed the drug resistance in
the … Overall, our study identified several drug-resistant hotspots in M pro that warrant close …

… infection sustained by SARS-CoV-2 and other human pathogenic coronaviruses, displaying
drug resistance profiles. The attention has been focused on antiviral drugs mainly targeting …

… developed pages (“Drug resistance” tab) providing … of drugs targeting SARS-CoV-2 virus
proteins. We initially focus on the M Pro , as a major drug target of an already approved drug …

… resistance on the SARS-CoV-2 nsp12 structure. Two functional domains can be defined,
hosting clusters of mutations, which likely provide resistance by related mechanisms. …

… emergence of drug resistance. In this study we implemented a strategy to pre-emptively
address drug resistance to protease inhibitors targeting the main protease (M pro ) of SARS-CoV-…

… resistance emergence choosing RdRp-remdesivir as a proof of concept. We address the
suitability of RdRp as a drug target for tackling SARS-CoV-… mutations in key drug binding motifs. …

… drug resistance to antiviral therapy as well as known and emergent variability in key
SARS-CoV-… The purpose is to stimulate deliberation about the need to consider drug resistance …

… Here, we selected drug-resistant viral populations by serially passaging SARS-CoV-2 in
vitro … The identification and characterisation of a drug resistant signature within the SARS-CoV-2 …