… drugs for blocking SARS-CoV-2 endocytosis Two broad approaches to developing drugs
against SARS-CoV… to virus, which may evolve drug resistance due to its high mutation rate [[49, …

… Protein fitness landscapes identify mutation- tolerant positions that may readily contribute
to drug resistance. These studies also elucidate mutation- sensitive residues …

… of a larger monitoring effort of drug resistance throughout the COVID-19 … SARS-CoV-2 from
patients treated with antivirals to provide early insights into the evolution or antiviral resistance…

… -type SARS-CoV-2 but failed to target the B.1.617 variant. Here, we focus on the biologics
drug … found to be efficacious on the wide-type SARS-CoV-2. By combining all-atom molecular …

… -2 was serially passaged in triplicate in the presence of GS-441524 or vehicle (DMSO) in
Vero E6 cells to generate drug resistance. Experiments were performed in two or more …

… Drug resistance poses a significant challenge in the development of effective therapies against
SARS-CoV… -like protease (3CLpro) that confer resistance to a novel non-covalent inhibitor…

… The ongoing SARS-CoV-2 pandemic has highlighted the importance of the rapid … QACs
are extensively used in SARS-CoV-2-related sanitization in clinical and household settings. …

… the role of FEP in identifying drug-resistance mutations. Our findings suggest that … resistant
strains and guiding the design of future inhibitors with reduced susceptibility to drug resistance…

… that prevent infection with SARS-CoV-2, and efforts to develop drugs and vaccines are …
how SARS-CoV-2 infects cells. Here we cloned, tagged and expressed 26 of the 29 SARS-CoV-2 …

… drug resistance can occur. Moreover, the limited number of proteins in a virus makes the
number of available targets small. Although SARS-CoV and SARS-CoV-… drug resistance. In this …