Inhibition of SARS-CoV-2 viral entry upon blocking N-and O-glycan elaboration

Q Yang, TA Hughes, A Kelkar, X Yu, K Cheng, S Park… - elife, 2020 - elifesciences.org
… In order to determine if the enhanced S1-S2 site proteolysis of Spike protein upon N-glycan
inhibition is the exclusive reason for reduced viral entry, we produced virus with a Spike …

Inhibition of Protein N-Glycosylation Blocks SARS-CoV-2 Infection

A Casas-Sanchez, A Romero-Ramirez, E Hargreaves… - MBio, 2022 - Am Soc Microbiol
… -glycans significantly reduces the spread of SARS-CoV-2 infection in vitro, including that of
several variants. As new SARS-CoV-… N-glycans, we hypothesized that the partial or complete …

Surface glycan modification of cellular nanosponges to promote SARS-CoV-2 inhibition

X Ai, D Wang, A Honko, Y Duan, I Gavrish… - Journal of the …, 2021 - ACS Publications
… higher inhibition of viral infectivity. Overall, our results show that surface glycan modification
is … boost cellular nanosponges against glycan-dependent viral threats such as SARS-CoV-2. …

Exploring the potential of chemical inhibitors for targeting post-translational glycosylation of coronavirus (SARS-CoV-2)

N Tripathi, B Goel, N Bhardwaj, RA Vishwakarma… - ACS …, 2022 - ACS Publications
… Especially, inhibition of the N-glycan biosynthesis pathway … The chemical inhibitors of
SARS-CoV-2 glycosylation could … inhibitors (both natural and synthetically designed inhibitors) of …

Inhibition of N-linked glycosylation by tunicamycin may contribute to the treatment of SARS-CoV-2

AA Dawood, MA Altobje - Microbial pathogenesis, 2020 - Elsevier
… in cells by inhibiting the first step in the biosynthesis of N-linked glycans in proteins resulting
in many misfolded proteins [7]. When the antibiotic blocks glycosylation of N-glycans, the …

Targeting spike glycans to inhibit SARS-CoV2 viral entry

AJ Guseman, LJ Rennick, S Nambulli… - Proceedings of the …, 2023 - National Acad Sciences
inhibits all tested variants of concern as well as SARS-CoV 2003, establishing that
multivalent glycan-targeting molecules have the potential to act as pan-coronavirus inhibitors. …

Man-specific lectins from plants, fungi, algae and cyanobacteria, as potential blockers for SARS-CoV, MERS-CoV and SARS-CoV-2 (COVID-19) coronaviruses …

A Barre, EJM Van Damme, M Simplicien, S Le Poder… - Cells, 2021 - mdpi.com
glycan probes for targeting the SARS-CoV, MERS-CoV, and … of complex glycans at the top
of the SARS-CoV and SARS-CoV-… the Fabaceae, compared to MERS-CoV spikes (Figure 29). …

Structural and kinetic analyses of holothurian sulfated glycans suggest potential treatment for SARS-CoV-2 infection

R Dwivedi, P Samanta, P Sharma, F Zhang… - Journal of Biological …, 2021 - ASBMB
… surface plasmon resonance of the wildtype SARS-CoV-2 spike (S)… Competitive surface
plasmon resonance inhibition analysis of … molecule for future investigations against SARS-CoV-2. …

[HTML][HTML] Glycan-directed SARS-CoV-2 inhibition by leek extract and lectins with insights into the mode-of-action of Concanavalin A

M Klevanski, H Kim, M Heilemann, T Kuner… - Antiviral Research, 2024 - Elsevier
… Allium porrum (leek) extract inhibiting SARS-CoV-2 infection in both … SARS-CoV-2 variants.
We used multiplex super-resolution microscopy to address lectin interactions with SARS-CoV

… activity by binding glycans in viral glycoprotein exhibits strong synergistic effect in combination with a pan-coronavirus fusion inhibitor targeting SARS-CoV-2 spike S2 …

Y Cai, W Xu, C Gu, X Cai, D Qu, L Lu, Y Xie, S Jiang - Virologica Sinica, 2020 - Springer
… is highly effective in inhibiting the pseudotyped and live SARS-CoV-2 infection by … SARS-CoV-2
S protein, which is in consistent with the mechanism by which GRFT inhibits SARS-CoV