… Understanding the mechanism underlying the SARS-CoV-2-induced cytokine storm is … that
SARS-CoV-2 ORF3a and host hypoxia-inducible factor-1α (HIF-1α) play key roles in the virus …

… To determine the effect of HIF-1α suppression in SARS-CoV-2 infected we studied the effect
of SARS-CoV-2 infection on target genes of HIF-1α (n=1256, as reported [Citation18]) in our …

… disease caused by the acute respiratory syndrome coronavirus 2 (SARS-CoV-2). As of July
… is known about the cellular mechanisms that underlie SARSCoV-2 (CoV-2) infection. The …

… that abnormal activation of the HIF-1 signaling pathway caused by SARS-CoV-2 infection is
… after SARS-CoV-2 infection (32). Therefore, in order to study the regulatory mechanism of HIF…

… The highly infectious SARS-CoV-2 virus primarily attacks pulmonary tissues and impairs …
activation of hypoxia inducible factor 1α (HIF-1α) and cell entry of SARS-CoV-2, since HIF-1α is …

… can be redirected as to the role that the HIF-1α molecule plays on SARS-CoV-2. … to
SARS-CoV-2, such as ACE2. Under chronic hypoxia ACE1 expression is upregulated by HIF-1α in …

The mechanistic interplay between SARS-CoV-2 infection, inflammation, and oxygen
homeostasis is not well defined. Here, we show that the hypoxia-inducible factor (HIF-1α) …

… the metabolic shift to glycolysis and to HIF-1α signaling. Therefore, although specific studies
… first phases of SARS-CoV-2 infection are M1-polarized and HIF-1α expressing and perform …

… Hypoxia and Roxadustat inhibit SARS-CoV-2 RNA replication, showing that post… HIF signaling
in regulating multiple aspects of SARS-CoV-2 infection and raises the potential use of HIF …

… A virus activates HIF-1 by … SARS-CoV-2 by some mechanism activates HIF-1 to manipulate
the host cell environment for its own benefits. Accordingly, SARS-CoV-2 in EC activates HIF-1…