A neutralizing human antibody binds to the N-terminal domain of the Spike protein of SARS-CoV-2

X Chi, R Yan, J Zhang, G Zhang, Y Zhang, M Hao… - Science, 2020 - science.org
… analyze the humoral antibody responses to SARS-CoV-2, … patients who had recovered
from SARS-CoV-2 infection. The … antibodies in plasma to different fragments of the SARS-CoV-2 …

[HTML][HTML] Cross-neutralization of SARS-CoV-2 by a human monoclonal SARS-CoV antibody

D Pinto, YJ Park, M Beltramello, AC Walls, MA Tortorici… - Nature, 2020 - nature.com
antibodies. Here we describe several monoclonal antibodies that target the S glycoprotein of
SARS-CoV-… with severe acute respiratory syndrome coronavirus (SARS-CoV) in 2003. One …

[HTML][HTML] Seasonal human coronavirus antibodies are boosted upon SARS-CoV-2 infection but not associated with protection

EM Anderson, EC Goodwin, A Verma, CP Arevalo… - Cell, 2021 - cell.com
… Identification of SARS-CoV-2-reactive antibodies in human sera collected prior to the COVID…
pre-pandemic SARS-CoV-2-reactive IgG antibodies in 431 human serum samples collected …

[HTML][HTML] Landscape of human antibody recognition of the SARS-CoV-2 receptor binding domain

AK Wheatley, P Pymm, R Esterbauer, MH Dietrich… - Cell Reports, 2021 - cell.com
antibody-based therapeutics. Here, the generation of a diverse panel of 91 human, neutralizing
monoclonal antibodies … These RBD antibodies ameliorate SARS-CoV-2 infection in mice …

Insights into SARS-CoV-2's mutations for evading human antibodies: sacrifice and survival

B Luan, T Huynh - Journal of medicinal chemistry, 2021 - ACS Publications
… (of the SARS-CoV-2’s spike protein) and human antibodies, … an aspartate in four other human
antibodies as highlighted in … Thus, it is likely that all of these antibodies may not be able to …

[HTML][HTML] Identification of human single-domain antibodies against SARS-CoV-2

Y Wu, C Li, S Xia, X Tian, Y Kong, Z Wang, C Gu… - Cell host & …, 2020 - cell.com
… Some of these antibodies neutralize SARS-CoV-2 by targeting a cryptic epitope located in
… rapid antibody isolation and identifies promising therapeutic anti-SARS-CoV-2 antibodies as …

A human antibody reveals a conserved site on beta-coronavirus spike proteins and confers protection against SARS-CoV-2 infection

P Zhou, M Yuan, G Song, N Beutler… - Science translational …, 2022 - science.org
… was to evaluate a previously discovered SARS-CoV-2 spike protein stem helix antibody,
CC40.8, for binding to and neutralization of diverse sarbecoviruses and SARS-CoV-2 VOCs, …

[HTML][HTML] Evolution of antibody immunity to SARS-CoV-2

C Gaebler, Z Wang, JCC Lorenzi, F Muecksch, S Finkin… - Nature, 2021 - nature.com
… The frequency distributions of human V genes in anti-SARS-CoV-2 antibodies from this …
downloaded from cAb-Rep 54 (a database of human shared BCR clonotypes available at https://…

Rapid identification of a human antibody with high prophylactic and therapeutic efficacy in three animal models of SARS-CoV-2 infection

W Li, C Chen, A Drelich, DR Martinez… - Proceedings of the …, 2020 - National Acad Sciences
… The recombinant RBD proteins was used to pan our naive human antibody phage display
libraries, which were made based on the antibody cDNA from a total of 490 healthy donors’ …

[HTML][HTML] SARS-CoV-2 neutralizing antibody structures inform therapeutic strategies

CO Barnes, CA Jette, ME Abernathy, KMA Dam… - Nature, 2020 - nature.com
… the structural correlates of SARS-CoV-2 neutralization, we solved eight new structures of
distinct COVID-19 human neutralizing antibodies 5 in complex with the SARS-CoV-2 spike …