SARS-coronavirus replication in human peripheral monocytes/macrophages

M Yilla, BH Harcourt, CJ Hickman, M McGrew, A Tamin… - Virus research, 2005 - Elsevier
human monocytes/macrophages can support SARS-CoV replication and, as such, participate
in the progression of SARS … monocyte/macrophage cultures inoculated with SARS-CoV did …

[HTML][HTML] Defining the innate immune responses for SARS-CoV-2-human macrophage interactions

MM Abdelmoaty, P Yeapuri, J Machhi… - Frontiers in …, 2021 - frontiersin.org
… To elucidate SARS-CoV-2-MP interactions we investigated transcriptomic and proteomic
profiles of human monocyte-derived macrophages. While expression of the SARS-CoV-2 …

[HTML][HTML] Naive human macrophages are refractory to SARS-CoV-2 infection and exhibit a modest inflammatory response early in infection

Z Zhang, R Penn, WS Barclay, ES Giotis - Viruses, 2022 - mdpi.com
… the ability of human macrophages to support SARS-CoV-2 replication. We infected
monolayers of primary human monocyte-derived macrophages (MDM) with a SARS-CoV-2 B.1 …

[HTML][HTML] SARS-CoV-2, SARS-CoV-1, and HIV-1 derived ssRNA sequences activate the NLRP3 inflammasome in human macrophages through a non-classical …

GR Campbell, RK To, J Hanna, SA Spector - Iscience, 2021 - cell.com
… -stranded RNA (GU-rich RNA) derived from SARS-CoV-2, SARS-CoV-1, and HIV-1 trigger a
human macrophages in the absence of pyroptosis, with GU-rich RNA from the SARS-CoV-2 …

[HTML][HTML] Differential effects of macrophage subtypes on SARS-CoV-2 infection in a human pluripotent stem cell-derived model

Q Lian, K Zhang, Z Zhang, F Duan, L Guo… - Nature …, 2022 - nature.com
… lung and macrophage co-culture system derived from humanSARS-CoV-2 infection. We
find that both classically polarized macrophages (M1) and alternatively polarized macrophages

[HTML][HTML] SARS-CoV-2 spike protein S1 subunit induces pro-inflammatory responses via toll-like receptor 4 signaling in murine and human macrophages

K Shirato, T Kizaki - Heliyon, 2021 - cell.com
… of SARS-CoV-2 spike protein S1 subunit (hereafter S1) on the pro-inflammatory responses
in murine and human macrophages. Murine peritoneal exudate macrophages produced pro-…

[HTML][HTML] The lung macrophage in SARS-CoV-2 infection: a friend or a foe?

Z Abassi, Y Knaney, T Karram, SN Heyman - Frontiers in Immunology, 2020 - frontiersin.org
… Herein we outline potential adverse effects of SARS-CoV2 on macrophages and … , while
macrophages play an important role in antiviral defense mechanisms, in the case of SARS-CoV, …

[HTML][HTML] The role of macrophages in the pathogenesis of SARS-CoV-2-associated acute respiratory distress syndrome

A Kosyreva, D Dzhalilova, A Lokhonina… - Frontiers in …, 2021 - frontiersin.org
macrophage phenotypes and functionalities. We describe participation of monocytes,
monocyte-derived and resident lung macrophages in SARS-CoV-2… of reprogrammed …

[HTML][HTML] CAR macrophages for SARS-CoV-2 immunotherapy

W Fu, C Lei, Z Ma, K Qian, T Li, J Zhao… - Frontiers in …, 2021 - frontiersin.org
… As macrophages have unique effector functions as a first-line … human macrophages
with chimeric antigen receptors (CARs) to reprogram their phagocytic activity against SARS-CoV-2. …

[HTML][HTML] Distinct SARS-CoV-2 RNA fragments activate Toll-like receptors 7 and 8 and induce cytokine release from human macrophages and microglia

T Wallach, M Raden, L Hinkelmann, M Brehm… - Frontiers in …, 2023 - frontiersin.org
… secretion from the murine macrophage line RAW264.7 through TLR7/8 (64). Our data show
that human macrophages significantly release TNF in response to the SARS-CoV-2 RNA …