[HTML][HTML] SARS-CoV-2 pathogenesis

MM Lamers, BL Haagmans - Nature reviews microbiology, 2022 - nature.com
cells targeted by SARS-CoV-2 during natural infection in humans are likely to be multiciliated
cells in the nasopharynx or trachea, or sustentacular cells … the positive-sense SARS-CoV-2 …

Cell entry mechanisms of SARS-CoV-2

J Shang, Y Wan, C Luo, G Ye, Q Geng… - Proceedings of the …, 2020 - National Acad Sciences
… as a comparison, we investigate these mechanisms at an essential step of viral infection:
the cell entry of SARS-CoV-2. Coronavirus entry into host cells is an important determinant of …

Signal transduction in SARSCoVinfected cells

T Mizutani - Annals of the new York Academy of Sciences, 2007 - Wiley Online Library
… of cell survival or death in SARS-CoV-infected cells in … -SARS-CoV drugs. This review
highlights recent progress regarding SARS-CoV biology, especially signal transduction in SARS-…

[HTML][HTML] Mechanisms of SARS-CoV-2 entry into cells

CB Jackson, M Farzan, B Chen, H Choe - … reviews Molecular cell …, 2022 - nature.com
… the structural and cellular foundations for understanding the multistep SARS-CoV-2 entry
process… , antibodies and other potential therapeutics targeting SARS-CoV-2 entry mechanisms. …

Syncytia formation by SARSCoV‐2‐infected cells

J Buchrieser, J Dufloo, M Hubert, B Monel… - The EMBO …, 2020 - embopress.org
… The viral and cellular mechanisms regulating the formation of … that SARS-CoV-2-infected
cells express the Spike protein (S) at their surface and fuse with ACE2-positive neighboring cells

SARS-CoV-2 spreads through cell-to-cell transmission

C Zeng, JP Evans, T King, YM Zheng… - Proceedings of the …, 2022 - National Acad Sciences
cell fusion activity. Interestingly, treatment of cocultured cells with endosomal entry inhibitors
impairs cell-to-cell … Compared with cell-free infection, cell-to-cell transmission of SARS-CoV-…

… of elevated levels of pro‐inflammatory cytokines in SARSCoVinfected ACE2+ cells in SARS patients: relation to the acute lung injury and pathogenesis of SARS

L He, Y Ding, Q Zhang, X Che, Y He… - The Journal of …, 2006 - Wiley Online Library
… detected in ACE2 + cells in the lungs … cells are the primary targets for SARS-CoV infection
in vivo in humans. High levels of PICs were expressed in the SARS-CoV-infected ACE2 + cells

[HTML][HTML] SARS-CoV-2 cell tropism and multiorgan infection

J Liu, Y Li, Q Liu, Q Yao, X Wang, H Zhang, R Chen… - Cell discovery, 2021 - nature.com
… e Schematic of SARS-CoV-2 multiorgan infection and cell tropism in the human body. …
The fact that SARS-CoV-2 infection in the vascular endothelial cells of various organs induces …

[HTML][HTML] Proteomics of SARS-CoV-2-infected host cells reveals therapy targets

D Bojkova, K Klann, B Koch, M Widera, D Krause… - Nature, 2020 - nature.com
… viral replication in cells. Our results reveal the cellular infection profile of SARS-CoV-2 and
… that underlie the modulation of host cells after infection with SARS-CoV-2. Furthermore, our …

The ORF7b protein of severe acute respiratory syndrome coronavirus (SARS-CoV) is expressed in virus-infected cells and incorporated into SARS-CoV particles

SR Schaecher, JM Mackenzie, A Pekosz - Journal of virology, 2007 - Am Soc Microbiol
… among sequenced SARS-CoV isolates, serial passage of SARS-CoV in Vero cells resulted
… We provide the first biochemical evidence for ORF7b expression in SARS-CoV-infected cells