Macrophages and dendritic cells are not the major source of pro-inflammatory cytokines upon SARS-CoV-2 infection

MA Niles, P Gogesch, S Kronhart… - Frontiers in …, 2021 - frontiersin.org
… in the production of pro-inflammatory cytokines is still under discussion. Surprisingly, we
could not observe production of pro-inflammatory cytokines by SARS-CoV-2 infected mDC, M1-, …

Association between inflammatory cytokines and anti-SARS-CoV-2 antibodies in hospitalized patients with COVID-19

X Jing, M Xu, D Song, T Yue, Y Wang, P Zhang… - Immunity & …, 2022 - Springer
… by the early responses of inflammatory cytokines. To investigate this … vaccines, cytokine
inhibitors and circulating SARS-CoV-2 … who received neither vaccines nor cytokine inhibitors. …

Lianhuaqingwen exerts anti-viral and anti-inflammatory activity against novel coronavirus (SARS-CoV-2)

L Runfeng, H Yunlong, H Jicheng, P Weiqi… - Pharmacological …, 2020 - Elsevier
… Pro-inflammatory cytokine expression levels upon SARS-CoV-… -229E and SARS-COV-2
increased the cytokine release such as … The change of cytokine profiles suggested that LH might …

Innate immune and inflammatory responses to SARS-CoV-2: Implications for COVID-19

SA Lowery, A Sariol, S Perlman - Cell Host & Microbe, 2021 - cell.com
… to SARS-CoV-2 in … on SARS-CoV-2 pathology, innate immune antagonism, and treatments.
We show that both interferon expression and signaling, as well as pro-inflammatory cytokine

SARS-CoV-2 infection and obesity: Common inflammatory and metabolic aspects

K Michalakis, I Ilias - Diabetes & Metabolic Syndrome: Clinical Research & …, 2020 - Elsevier
… nucleus leads to a cascade of pro-inflammatory cytokines [12]. Among all interleukins, IL-6
was found to be associated with a highly pathogenic SARS-CoV-2 infection, due to enhanced …

SARS-CoV-2 triggers inflammatory responses and cell death through caspase-8 activation

S Li, Y Zhang, Z Guan, H Li, M Ye, X Chen… - Signal transduction and …, 2020 - nature.com
… Here we report that SARS-CoV-2 infection of lung epithelial cells induces … inflammatory
cytokines including IL-1β into the bioactive form. IL-1β was then secreted through the SARS-CoV-…

[HTML][HTML] Synergism of TNF-α and IFN-γ triggers inflammatory cell death, tissue damage, and mortality in SARS-CoV-2 infection and cytokine shock syndromes

R Karki, BR Sharma, S Tuladhar, EP Williams… - Cell, 2021 - cell.com
… multiple inflammatory cytokines are produced by innate immune cells during SARS-CoV-2 …
IFN-γ induced inflammatory cell death characterized by inflammatory cell death, PANoptosis. …

[PDF][PDF] Coronavirus-19 (SARS-CoV-2) induces acute severe lung inflammation via IL-1 causing cytokine storm in COVID-19: a promising inhibitory strategy

P Conti, A Caraffa, CE Gallenga, R Ross… - J Biol Regul Homeost …, 2020 - researchgate.net
… Here, we report that SARS-CoV-2 induces IL-1 in macrophages … inflammatory cytokines.
Since IL-1 is toxic, its production from ubiquitous MCs and macrophages activated by SARS-CoV

Activation of NF-κB and induction of proinflammatory cytokine expressions mediated by ORF7a protein of SARS-CoV-2

CM Su, L Wang, D Yoo - Scientific reports, 2021 - nature.com
… -2, their viral proteins may possess conserved strategies to manipulate cytokine response. …
SARS-CoV-2 proteins that were able to modulate NF-κB response and inflammatory cytokine

Immune response to SARSCoV‐2 and mechanisms of immunopathological changes in COVID‐19

AK Azkur, M Akdis, D Azkur, M Sokolowska… - Allergy, 2020 - Wiley Online Library
… Several immune pathways and pro-inflammatory cytokines were induced by SARS-CoV-2
infection, notably CC chemokine ligand (CCL)2, CXC motif chemokine ligand(CXCL)2, CCL8, …