[PDF][PDF] Synergism of TNF-α and IFN-γ triggers inflammatory cell death, tissue damage, and mortality in SARS-CoV-2 infection and cytokine shock syndromes

R Karki, BR Sharma, S Tuladhar, EP Williams… - Cell, 2021 - cell.com
inflammatory cytokines released during SARSCoV-2 infection to induce cell death, we treated
bone marrow-derived macrophages (BMDMs) with the cytokinesSARSCoV-2. None of the …

Cytokine response in SARS-CoV-2 infection in the elderly

S Sherwani, MWA Khan - Journal of Inflammation Research, 2020 - Taylor & Francis
… patients with severe disease had very low levels of the anti-inflammatory cytokine, IL-10,
Citation31 individuals with lethal SARS showed increased levels of pro-inflammatory cytokines

Activation and pro-inflammatory cytokine production by unswitched memory B cells during SARS-CoV-2 infection

MJ Castleman, AL Santos, KE Lesteberg… - Frontiers in …, 2023 - frontiersin.org
… the TNFα pro-inflammatory cytokine drives the loss … inflammation cytokines in response to
viral ligands, B cells themselves may likely contribute to disease pathology during SARS-CoV

[PDF][PDF] Coronavirus COV-19/SARS-CoV-2 affects women less than men: clinical response to viral infection

P Conti, A Younes - J Biol Regul Homeost Agents, 2020 - researchgate.net
… mast cells, causing an inflammatory cytokine storm with respiratory distress syndrome. …
CoV-19 can promote vascularization and hyperemia with the production of inflammatory cytokines

The role of IL-6 and other mediators in the cytokine storm associated with SARS-CoV-2 infection

A Copaescu, O Smibert, A Gibson, EJ Phillips… - Journal of Allergy and …, 2020 - Elsevier
… of inflammatory cytokines. This pathway is represented only in Fig 3, A, and replaced by
the word “SIGNAL” in Fig 3, B. A, Classic signaling, which is restricted to several cell types, is …

SARS-CoV-2/ACE2 interaction suppresses IRAK-M expression and promotes pro-inflammatory cytokine production in macrophages

I Pantazi, AA Al-Qahtani, FS Alhamlan… - Frontiers in …, 2021 - frontiersin.org
… In summary, our study demonstrated that SARS-CoV-2 promoted inflammatory cytokine
to TLR signals, supporting the development of cytokine storm observed in COVID-19 patients. …

Patients with immune-mediated inflammatory diseases receiving cytokine inhibitors have low prevalence of SARS-CoV-2 seroconversion

D Simon, K Tascilar, G Krönke, A Kleyer… - Nature …, 2020 - nature.com
… (IMIDs) of the joints, gut and skin are treated with inhibitors of inflammatory cytokines. These
… incidence of SARS-CoV-2 seroconversion in IMID patients treated with cytokine inhibitors …

Altered cytokine levels and immune responses in patients with SARS-CoV-2 infection and related conditions

R Noroozi, W Branicki, K Pyrc, PP Łabaj, E Pospiech… - Cytokine, 2020 - Elsevier
… Wong et al. have assessed a number of cytokines and chemokines in patients affected with
SARS. They detected significant increase in Th1 cytokine IFN-γ, inflammatory cytokines IL-1, …

Inflammasomes and SARS-CoV-2 infection

J Kaivola, TA Nyman, S Matikainen - Viruses, 2021 - mdpi.com
… The disease induced by SARS-CoV-2 is called COVID-19. A majority … SARS-CoV-2 infections
are associated with excessive production of pro-inflammatory cytokines, so called “cytokine

Variable induction of pro-inflammatory cytokines by commercial SARS CoV-2 spike protein reagents: potential impacts of LPS on in vitro modeling and pathogenic …

W Ouyang, T Xie, H Fang, C Gao, T Stantchev… - International journal of …, 2021 - mdpi.com
coronavirus 2 (SARS CoV-2) is associated with poor clinical outcomes. Like SARS CoV-1,
SARS CoV-2 … As SARS CoV-1 spike protein is reported to induce cytokine production, we …