Cytokine profiles as potential prognostic and therapeutic markers in SARS-CoV-2-induced ARDS

F Salton, P Confalonieri, G Campisciano… - Journal of clinical …, 2022 - mdpi.com
… or a reduced expression of GRα following a sustained exposure to inflammatory
cytokines (eg, IL-1β) and an increased activation of inflammation-related genes [19,20,21,22,23]. …

The DHODH inhibitor PTC299 arrests SARS-CoV-2 replication and suppresses induction of inflammatory cytokines

J Luban, RA Sattler, E Mühlberger, JD Graci, L Cao… - Virus research, 2021 - Elsevier
… RNA viruses, with a specific focus on SARS-CoV-2, and the ability of the drug to attenuate
the excessive production of inflammatory cytokines. Our results indicate that that PTC299 has …

Cytokine regulation in SARS coronavirus infection compared to other respiratory virus infections

T Okabayashi, H Kariwa, S Yokota, S Iki… - Journal of medical …, 2006 - Wiley Online Library
… of inflammatory response, were upregulated by SARS-CoV … of inflammatory cytokine and
dysregulation of cytokine … of SARSCoV on IFN system and proinflammatory cytokine production …

Overview: systemic inflammatory response derived from lung injury caused by SARS-CoV-2 infection explains severe outcomes in COVID-19

RB Polidoro, RS Hagan, R de Santis Santiago… - Frontiers in …, 2020 - frontiersin.org
… Following exposure to air pollution particles, alveolar macrophages and epithelial cells
increase the production of pro-inflammatory cytokines capable of stimulating the bone marrow, …

Virology, transmission, and pathogenesis of SARS-CoV-2

M Cevik, K Kuppalli, J Kindrachuk, M Peiris - bmj, 2020 - bmj.com
… Increased levels of pro-inflammatory cytokines correlate with severe pneumonia and increased
… In people with severe illness, increased plasma concentrations of inflammatory cytokines

Cytokine storm induced by SARS-CoV-2 infection: The spectrum of its neurological manifestations

P Thepmankorn, J Bach, A Lasfar, X Zhao, S Souayah… - Cytokine, 2021 - Elsevier
… pro-inflammatory cytokine levels, which leads to overwhelming systemic inflammation, …
The cytokine storm has also been observed in SARS, MERS, H5N1 influenza, and H7N9 …

[PDF][PDF] COVID-19 induced by SARS-CoV-2 causes Kawasaki-like disease in children: Role of pro-inflammatory and anti-inflammatory cytokines

R Ross, P Conti - J. Biol. Regul. Homeost. Agents, 2020 - researchgate.net
… aimed at blocking cytokines (18). This is the first time to our knowledge that pro-inflammatory
cytokines are reported to mediate Kawasaki-like disease caused by SARS-CoV-2. …

Comparison of the characteristics of cytokine storm and immune response induced by SARS-CoV, MERS-CoV, and SARS-CoV-2 infections

T Liu, M Feng, Z Wen, Y He, W Lin… - Journal of Inflammation …, 2021 - Taylor & Francis
… This review compares the characters of cytokine storms and immune responses caused by
coronavirus (SARS-CoV), Middle East respiratory syndrome-coronavirus (MERS-CoV), and …

SARS-CoV-2 spike protein induces inflammation via TLR2-dependent activation of the NF-κB pathway

S Khan, MS Shafiei, C Longoria, JW Schoggins… - Elife, 2021 - elifesciences.org
… Our finding that SARS- CoV- 2 S protein is a potent viral PAMP involved in the induction of
inflammatory cytokines and chemokines via TLR2- dependent activation of the NF-κB pathway…

SARS-CoV-2 mediated lung inflammatory responses in host: targeting the cytokine storm for therapeutic interventions

P Asrani, MI Hassan - Molecular and Cellular Biochemistry, 2021 - Springer
… The enhancement in ACE2 shedding can be mediated by both SARS-CoV and SARS-CoV-2
infection and further release of inflammatory cytokines such as IL-1β and TNF-α by viral …