Innate immune and inflammatory responses to SARS-CoV-2: Implications for COVID-19

SA Lowery, A Sariol, S Perlman - Cell Host & Microbe, 2021 - cell.com
… unbalanced innate immune response. Here, we review the mechanisms by which SARS-CoV-2
both activates and antagonizes the IFN and inflammatory response following infection, …

Understanding SARS-CoV-2-mediated inflammatory responses: from mechanisms to potential therapeutic tools

Y Fu, Y Cheng, Y Wu - Virologica Sinica, 2020 - Springer
… Given that there are very few mechanistic studies on inflammatory responses in SARS-CoV
infection, we focus only on discussing limited mechanisms that might be involved. For the …

Overview: systemic inflammatory response derived from lung injury caused by SARS-CoV-2 infection explains severe outcomes in COVID-19

RB Polidoro, RS Hagan, R de Santis Santiago… - Frontiers in …, 2020 - frontiersin.org
… book chapter “Systemic Inflammatory Response Induced by Lung Inflammation” by Hiraiwa
… ARDS caused by SARS-CoV-2 is characterized by a rapidly induced inflammatory response

SARS-CoV-2 triggers inflammatory responses and cell death through caspase-8 activation

S Li, Y Zhang, Z Guan, H Li, M Ye, X Chen… - Signal transduction and …, 2020 - nature.com
… We further analyzed whether SARS-CoV-2 infection induces inflammatory responses and …
of SARS-CoV-2. The HFH4-hACE2 mice were intranasally infected with SARS-CoV-2 or mock-…

[HTML][HTML] Effects of a major deletion in the SARS-CoV-2 genome on the severity of infection and the inflammatory response: an observational cohort study

BE Young, SW Fong, YH Chan, TM Mak, LW Ang… - The lancet, 2020 - thelancet.com
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants with
a 382-nucleotide deletion (∆382) in the open reading frame 8 (ORF8) region of the genome …

HIF-1α promotes SARS-CoV-2 infection and aggravates inflammatory responses to COVID-19

M Tian, W Liu, X Li, P Zhao, MA Shereen… - … and Targeted Therapy, 2021 - nature.com
… We next evaluated the effects of SARS-CoV-2 on immune and inflammatory responses
between young and elderly COVID-19 patients. Notably, among 143 patients, 49 were young …

Dynamics of inflammatory responses after SARS-CoV-2 infection by vaccination status in the USA: a prospective cohort study

X Zhu, KA Gebo, AG Abraham, F Habtehyimer… - The Lancet …, 2023 - thelancet.com
Background Cytokines and chemokines play a critical role in the response to infection and
vaccination. We aimed to assess the longitudinal association of COVID-19 vaccination with …

SARS-CoV-2 pathogenesis

MM Lamers, BL Haagmans - Nature reviews microbiology, 2022 - nature.com
… as a result of dysfunctional immune responses. We discuss how this may … inflammation and
coagulation, while an influx of immune cells leads to overexuberant inflammatory responses

Neurological complications associated with the blood-brain barrier damage induced by the inflammatory response during SARS-CoV-2 infection

I Alquisiras-Burgos, I Peralta-Arrieta… - Molecular …, 2021 - Springer
… brain injury after SARS-CoV-2 infection. We proposed that potential routes of SARS-CoV-2
neuro-… Additionally, activation of the inflammatory response against the infection represents a …

Long-term SARS-CoV-2-specific immune and inflammatory responses in individuals recovering from COVID-19 with and without post-acute symptoms

MJ Peluso, AN Deitchman, L Torres, NS Iyer… - Cell Reports, 2021 - cell.com
coronavirus 2 (SARS-CoV-2)-specific T cell responses, soluble markers of inflammation, …
in 70 individuals with PCR-confirmed SARS-CoV-2 infection. Participants represent a spectrum …