SARS-CoV-2 spike protein induces paracrine senescence and leukocyte adhesion in endothelial cells

K Meyer, T Patra, Vijayamahantesh, R Ray - Journal of virology, 2021 - Am Soc Microbiol
leukocyte adhesion using a fluorometric assay on the human monocyte cell line THP-1. A
significant cellular adhesion … in the presence of CM from SARS-CoV-2 spike-expressing A549 …

[HTML][HTML] … cell adhesion molecules and leukocyte apoptosis in the lymphopenia and thrombocytopenia of patients with severe acute respiratory syndrome (SARS)

RF Chen, JC Chang, WT Yeh, CH Lee, JW Liu… - Microbes and …, 2006 - Elsevier
… sVCAM-1 perhaps acts as a competitive ligand to inhibit leukocyte adhesion to inflamed … in
adhesion and chemotaxis toward endothelium of circulating lymphocytes. Patients with SARS

The spike protein of SARS-CoV-2 induces endothelial inflammation through integrin α5β1 and NF-κB signaling

JP Robles, M Zamora, E Adan-Castro… - Journal of Biological …, 2022 - ASBMB
… To evaluate whether the spike-induced leukocyte adhesion to ECs is dependent on NF-κB
activation, we tested the effect of BAY 11-7085 upon spike-induced, spike receptor–binding …

[HTML][HTML] Endothelial cell, myeloid, and adaptive immune responses in SARSCoV‐2 infection

N Degauque, A Haziot, S Brouard, N Mooney - The FASEB Journal, 2021 - ncbi.nlm.nih.gov
… Here, we review endothelial cell responses in inflammation and infection due to SARSCoV
of Human Leukocyte Antigens (HLA) molecules, co‐stimulatory and adhesion molecules …

Endothelial dysfunction and SARS-CoV-2 infection: association and therapeutic strategies

H Deng, TX Tang, D Chen, LS Tang, XP Yang… - Pathogens, 2021 - mdpi.com
… supports leukocyte recruitment and adhesion and … leukocytes, especially in regulating
inflammatory pathways and preventing infections [17]. It has been found that the levels of adhesion

[HTML][HTML] Endothelial cells and SARS-CoV-2: An intimate relationship

LC Barbosa, TL Goncalves, LP de Araujo… - Vascular …, 2021 - Elsevier
… A TJ also limit transcellular transport through the vessel wall and assists maintain low levels
of leukocyte adhesion molecules expression, with a focus on limiting the entry of immune …

Leukocyte trafficking to the lungs and beyond: lessons from influenza for COVID-19

R Alon, M Sportiello, S Kozlovski, A Kumar… - Nature Reviews …, 2021 - nature.com
leukocyte trafficking molecules orchestrate this recruitment and how excessive accumulation
of specific leukocyte … experimental data on leukocyte trafficking in SARS-CoV-2 infection in …

Long-term hypercoagulability, endotheliopathy and inflammation following acute SARS-CoV-2 infection

A Boccatonda, E Campello, C Simion… - Expert Review of …, 2023 - Taylor & Francis
… promote leukocyte adhesion and … SARS-CoV-2 infection results in a pro-adhesive and
chemokine-secreting phenotype which in turn facilitates the recruitment of circulating leukocytes

The spike protein of SARS-CoV-2 induces endothelial inflammation through integrin α5β1 and NF-κB

JP Robles, M Zamora, GM de la Escalera, C Clapp - bioRxiv, 2021 - biorxiv.org
… To evaluate whether the spike-induced leukocyte adhesion to EC is dependent on NF-κB
activation, we tested the effect of BAY11-7085 upon spike-, spike receptor-binding domain-, …

Endothelial cells are not productively infected by SARSCoV‐2

L Schimmel, KY Chew, CJ Stocks… - Clinical & …, 2021 - Wiley Online Library
… whether the abortive SARS-CoV-2 infection observed in endothelial cells induces a pro-inflammatory
response. We assessed expression of the leukocyte adhesion molecule, ICAM-1, …