Insights to SARS-CoV-2 life cycle, pathophysiology, and rationalized treatments that target COVID-19 clinical complications

IP Trougakos, K Stamatelopoulos, E Terpos… - Journal of Biomedical …, 2021 - Springer
… Here we discuss SARS-CoV-2 life cycle and a number of approaches aiming to suppress
viral infection rates or propagation; increase virus antigen presentation in order to activate a …

Drugs targeting various stages of the SARS-CoV-2 life cycle: Exploring promising drugs for the treatment of Covid-19

R Poduri, G Joshi, G Jagadeesh - Cellular signalling, 2020 - Elsevier
life cycle are ongoing to examine potential effectiveness for the prevention and treatment of
the infection. This review summarizes the SARS-CoV-2 virus life cyclecoronavirus. The viral …

Viroporins: Structure, function, and their role in the life cycle of SARS-CoV-2

U Breitinger, NS Farag, H Sticht… - The international journal of …, 2022 - Elsevier
… Contributions of SARS-CoV-2 viroporins to the viral life cycle are discussed with respect to
… Viroporin sequences of new variants of concern (α–ο) of SARS-CoV-2 are briefly reviewed …

The life cycle of SARS coronavirus in Vero E6 cells

Z Qinfen, C Jinming, H Xiaojun… - Journal of medical …, 2004 - Wiley Online Library
… the life cycle of severe acute respiratory syndrome-associated coronavirus (SARS CoV) in
… We propose a scheme of the life cycle of SARS coronavirus and discuss the mechanism of …

A novel cell culture system modeling the SARS-CoV-2 life cycle

X Ju, Y Zhu, Y Wang, J Li, J Zhang, M Gong… - PLoS …, 2021 - journals.plos.org
… virion assembly (SARS-CoV-2 GFP/ΔN trVLP). The complete viral life cycle can be achieved
… cells ectopically expressing SARS-CoV or SARS-CoV-2 N proteins, but not MERS-CoV N. …

[HTML][HTML] Drug discovery and development targeting the life cycle of SARS-CoV-2

H Su, Y Xu, H Jiang - Fundamental Research, 2021 - Elsevier
… Strategies to block key steps of the life cycle of SARS-CoV-2. Multiple steps in the life cycle
of the virus are presented, including the binding of the spike protein to ACE2, membrane …

The SARS-CoV-2 nucleocapsid protein: its role in the viral life cycle, structure and functions, and use as a potential target in the development of vaccines and …

W Wu, Y Cheng, H Zhou, C Sun, S Zhang - Virology journal, 2023 - Springer
… , many other SARS-CoV-2 proteins play an equally important role in the virus life cycle, but
… Therefore, this paper focuses on the SARS-CoV-2 life cycle, the structure and function of N …

An update on COVID-19: SARS-CoV-2 life cycle, immunopathology, and BCG vaccination

SM Khade, SM Yabaji, J Srivastava - Preparative biochemistry & …, 2021 - Taylor & Francis
… Phases of the life cycle of SARS-CoV in the host cells containing ACE2 receptor. The life
cycle of SARS-CoV starts when viral protein S binds to the ACE2 cell receptor, and this binding …

MicroRNAs and SARS-CoV-2 life cycle, pathogenesis, and mutations: biomarkers or therapeutic agents?

F Abedi, R Rezaee, AW Hayes, S Nasiripour, G Karimi - Cell Cycle, 2021 - Taylor & Francis
… human and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) microRNAs (…
the importance of miRNAs in the SARS-CoV-2 life cycle, pathogenesis, and genomic mutations…

[PDF][PDF] SARS-CoV-2 morphology, genome, life cycle and our bodies' immune response: a review

I Zatla, L Boublenza, H Hassaine - Virology, 2021 - researchgate.net
… A novel coronavirus strain has been … of SARSCoV-2, the virus that causes COVID-19,
covering the general structure of the virus, its genetics and its process of replication. SARS-CoV-2 …