[HTML][HTML] The theory and practice of the viral dose in neutralization assay: Insights on SARS-CoV-2 “doublethink” effect

A Manenti, E Molesti, M Maggetti, A Torelli… - Journal of Virological …, 2021 - Elsevier
… Our results show that, with the lower dose (25 TCID 50 ) in the majority of the cases the
MN titres are higher of one or two dilution steps (Fig. 1A and B). This is also confirmed for the …

[HTML][HTML] SARS-CoV-2 neutralizing antibody LY-CoV555 in outpatients with Covid-19

P Chen, A Nirula, B Heller, RL Gottlieb… - … England Journal of …, 2021 - Mass Medical Soc
… -dose trial conducted at 41 centers in the United States, all the patients had positive results
on testing for SARS-CoV-… four of these groups: LY-CoV555 at doses of 700 mg, 2800 mg, and …

[HTML][HTML] Safety, tolerability, and immunogenicity of an inactivated SARS-CoV-2 vaccine in healthy adults aged 18–59 years: a randomised, double-blind, placebo …

Y Zhang, G Zeng, H Pan, C Li, Y Hu, K Chu… - The Lancet infectious …, 2021 - thelancet.com
… (low dose CoronaVac [3 μg per 0·5 mL of aluminium hydroxide diluent per dose) then another
36 were assigned to block 2 (high-dose … , to either two doses of CoronaVac or two doses of …

[HTML][HTML] Antibody responses to SARS-CoV-2 vaccines in 45,965 adults from the general population of the United Kingdom

J Wei, N Stoesser, PC Matthews, D Ayoubkhani… - Nature …, 2021 - nature.com
… Using data from all participants in the national survey 22 , we found a 76% reduction in
symptomatic SARS-CoV-2 infection following a first vaccine dose, rising to 95% after two …

Neurological autoimmune diseases following vaccinations against SARSCoV‐2: a case series

LD Kaulen, S Doubrovinskaia… - European journal of …, 2022 - Wiley Online Library
… following SARS-CoV-2 vaccinations are characterized. Given the assumed low incidence …
The number of individuals who only received their second dose during the inclusion period …

[HTML][HTML] Measuring immunity to SARS-CoV-2 infection: comparing assays and animal models

DS Khoury, AK Wheatley, MD Ramuta… - Nature Reviews …, 2020 - nature.com
… When assessing protective efficacy in animal models, we suggest it may be beneficial to
use a low-dose challenge model with sequence-verified virus stocks, in which animals are …

[HTML][HTML] A single dose of recombinant VSV-∆ G-spike vaccine provides protection against SARS-CoV-2 challenge

Y Yahalom-Ronen, H Tamir, S Melamed, B Politi… - Nature …, 2020 - nature.com
… We show that a single-dose vaccination results in a rapid and potent induction of SARS-CoV-2
neutralizing antibodies. Importantly, vaccination protects hamsters against SARS-CoV-2 …

[HTML][HTML] A single-dose mRNA vaccine provides a long-term protection for hACE2 transgenic mice from SARS-CoV-2

Q Huang, K Ji, S Tian, F Wang, B Huang, Z Tong… - Nature …, 2021 - nature.com
… the high dose (mean value 727) (Fig. 2b). Live SARS-CoV-2 neutralization assays
demonstrated that all of the vaccinated mice except one inoculated with the low dose developed …

[HTML][HTML] Reduced sensitivity of SARS-CoV-2 variant Delta to antibody neutralization

D Planas, D Veyer, A Baidaliuk, I Staropoli… - Nature, 2021 - nature.com
… In individuals who had not previously been infected with SARS-CoV-2, a single dose of
either the Pfizer or the AstraZeneca vaccine induced a barely detectable level of neutralizing …

Effect of an inactivated vaccine against SARS-CoV-2 on safety and immunogenicity outcomes: interim analysis of 2 randomized clinical trials

S Xia, K Duan, Y Zhang, D Zhao, H Zhang, Z Xie, X Li… - Jama, 2020 - jamanetwork.com
… had results for 3 different doses (low, medium, and high doses) and 3 … (low-, medium-,
and high-dose groups with 3 injections [days 0, 28, and 56; n = 80 in each group], a medium-dose