[HTML][HTML] SARS-CoV-2 neutralizing antibody LY-CoV555 in outpatients with Covid-19

P Chen, A Nirula, B Heller, RL Gottlieb… - … England Journal of …, 2021 - Mass Medical Soc
… The discovery of LY-CoV555 and its passive protection against SARS-CoV-2 in nonhuman
LY-CoV555 or placebo was administered within 3 days after positive results on SARS-CoV-2 …

The neutralizing antibody, LY-CoV555, protects against SARS-CoV-2 infection in nonhuman primates

BE Jones, PL Brown-Augsburger, KS Corbett… - Science translational …, 2021 - science.org
LY-CoV555 bound to the severe acute respiratory distress syndrome coronavirus-2 (SARS-CoV-…
Prophylactic treatment with LY-CoV555 protected the upper and lower respiratory tracts …

LY-CoV555, a rapidly isolated potent neutralizing antibody, provides protection in a non-human primate model of SARS-CoV-2 infection

BE Jones, PL Brown-Augsburger, KS Corbett… - BioRxiv, 2020 - biorxiv.org
… (10) LY-CoV555 was observed to bind to an epitope … (5, 20, 21) Based on the crystal structure,
the LY-CoV555 epitope … of LY-CoV555 Fab complexes in which the LY-CoV555 Fab was …

[PDF][PDF] Complete map of SARS-CoV-2 RBD mutations that escape the monoclonal antibody LY-CoV555 and its cocktail with LY-CoV016

TN Starr, AJ Greaney, AS Dingens, JD Bloom - Cell Reports Medicine, 2021 - cell.com
LY-CoV016). In addition, the L452R mutation in the B.1.429 lineage escapes LY-CoV555.
Furthermore, we identify single amino acid changes that escape the combined LYCoV555+LY-…

Emerging antibody-based therapeutics against SARS-CoV-2 during the global pandemic

Y Sun, M Ho - Antibody therapeutics, 2020 - academic.oup.com
… /LY-CoV555) for the treatment of mild-to-moderate COVID-19. This review outlines the
development of neutralizing antibodies against SARS-CoV-… of SARS-CoV-2 and SARS-CoV might …

Anti-SARS-CoV-2 neutralizing monoclonal antibodies: clinical pipeline

M Tuccori, S Ferraro, I Convertino, E Cappello… - MAbs, 2020 - Taylor & Francis
… combination of LY-CoV555 and LY-… LY-CoV555 monotherapy and placebo. Citation22
Preliminary results of the BLAZE-1 study, provided only for the comparison between LY-CoV555

Bamlanivimab does not neutralize two SARS-CoV-2 variants carrying E484K in vitro

M Widera, A Wilhelm, S Hoehl, C Pallas, N Kohmer… - MedRxiv, 2021 - medrxiv.org
… (mAb) bamlanivimab (LY-CoV555) prevents viral attachment … , showing that LY-CoV555 is
ineffective against B.1.351 but is … bamlanivimab (LY-CoV555) using live SARS-CoV-2 isolates. …

Neutralizing antibodies against SARS-CoV-2: current understanding, challenge and perspective

Y Huang, H Sun, H Yu, S Li, Q Zheng… - Antibody …, 2020 - academic.oup.com
… Of these, LY-CoV555 is the first antibody to enter into phase 1 clinical trials in the world
and the NAb CB6, termed as JS016 in the clinical trial, is in the steady progress of phase 1 in …

Structure–function analysis of resistance to bamlanivimab by SARS-CoV-2 variants Kappa, Delta, and Lambda

S Liu, T Huynh, CB Stauft, TT Wang… - Journal of Chemical …, 2021 - ACS Publications
SARS-CoV-2 but failed to target the Kappa variant. Here, we focus on the drug LY-CoV555
that … LY-CoV555 recognizes an epitope site in the RBD overlapping the binding site of hACE2 …

[HTML][HTML] In vivo monoclonal antibody efficacy against SARS-CoV-2 variant strains

RE Chen, ES Winkler, JB Case, ID Aziati, TL Bricker… - Nature, 2021 - nature.com
… Mice treated with 2B04/47D11 or LY-CoV555 also showed greater virus breakthrough than
… than the other mAb cocktails, and LY-CoV555 mAb treatment conferred virtually no protection …