In vivo monoclonal antibody efficacy against SARS-CoV-2 variant strains

RE Chen, ES Winkler, JB Case, ID Aziati, TL Bricker… - Nature, 2021 - nature.com
… Mice treated with 2B04/47D11 or LY-CoV555 also showed greater virus breakthrough than
… than the other mAb cocktails, and LY-CoV555 mAb treatment conferred virtually no protection …

[PDF][PDF] Targeting SARS-CoV-2 with therapeutic monoclonal antibodies

S Hussain - Precision Med Res, 2021 - tmrjournals.com
… ongoing, with the medication company "Lilly" using LY-CoV555 neutralizing MAbs against
the spike protein. The neutralizing antibody LY-CoV555, at a dosage of 2800 mg, appeared to …

A neutralizing monoclonal antibody for hospitalized patients with Covid-19

Activ-3/Tico Ly-CoV555 Study … - New England Journal of …, 2021 - Mass Medical Soc
… odds ratio of a better outcome with LY-CoV555 than with placebo using proportional-odds …
the primary safety analysis, which compared LY-CoV555 with placebo with respect to the …

An infectious SARS-CoV-2 B. 1.1. 529 Omicron virus escapes neutralization by therapeutic monoclonal antibodies

LA VanBlargan, JM Errico, PJ Halfmann, SJ Zost… - Nature medicine, 2022 - nature.com
… ); LY-CoV555/LY-CoV016 (synthesized based on bamlanivimab and etesevimab sequences
from Eli Lilly); CT-P59 (synthesized based on regdanvimab sequences from Celltrion); and …

in silico Assessment of Antibody Drug Resistance to Bamlanivimab of SARS-CoV-2 Variant B.1.617

L Zhang, T Huynh, B Luan - bioRxiv, 2021 - biorxiv.org
… antibody that can neutralize the wide-type SARS-CoV-2 but failed to target the B.… LY-CoV555
that is a monoclonal antibody isolated from a convalescent COVID-19 patient. LY-CoV555

Therapeutic antibodies under development for SARSCoV‐2

Z Ma, MM Zhu, S Zhang, K Qian, C Wang, W Fu, C Lei… - View, 2022 - Wiley Online Library
… initiated a Phase 1 study on LY-CoV555 and had completed enrolling patients and … LY-COV555
group was 1.6% compared with 6.3% in the placebo group, suggesting that LY-COV555

Molecular rationale for SARS-CoV-2 spike circulating mutations able to escape bamlanivimab and etesevimab monoclonal antibodies

E Laurini, D Marson, S Aulic, A Fermeglia, S Pricl - Scientific Reports, 2021 - nature.com
… binding domain of the SARS-CoV-2 spike protein (S-RBD CoV‑2 ) in evading the
immune surveillance effects elicited by the two Eli Lilly LY-CoV555/bamlanivimab and LY-CoV016/…

[HTML][HTML] Monoclonal neutralizing antibodies against SARS-COV-2 S protein

LD Cheng, P Li, YC Lin, HX Hu, Y Zhang… - American Journal of …, 2024 - ncbi.nlm.nih.gov
… We found that AUC 0-192 hr of all drugs was higher, of which 14F4HL was twice as high
as positive control LY-CoV555, indicating that the total amount of 14F4HL and the elimination …

Resistance of SARS-CoV-2 Omicron BA. 1 and BA. 2 variants to vaccine-elicited sera and therapeutic monoclonal antibodies

H Zhou, BM Dcosta, NR Landau, T Tada - Viruses, 2022 - mdpi.com
… of the REGN SARS-CoV-2 cocktail neutralized D614G and Delta but not BA.1 or BA.2.
Similarly, LY-CoV555 and LY-CoV016 neutralized D614G and Delta (although LY-CoV555 had …

High individual heterogeneity of neutralizing activities against the original strain and nine different variants of SARS-CoV-2

R Jaafar, C Boschi, S Aherfi, A Bancod, M Le Bideau… - Viruses, 2021 - mdpi.com
… For the human monoclonal antibody, we selected LY-CoV555 to be tested along with the
serum samples in the microneutralisation test (MNT) and used it as our positive control for the …