… For LY- CoV016, K417N is sufficient for escape (Figure 1D, green), whereas both LY- CoV555
and … Overall, we find that BA.1 escape from LY- CoV016, LY- CoV555, and REGN10987 is …

… -binding domain (RBD) of the SARS-CoV-2 virus's spike protein, and thereby blocks the
RBD's … Notice that three LY-CoV555 Fab fragments bind to one spike trimer. LY-CoV555 was …

… The emergence of SARS-CoV-2 variants necessitates rational assessment of their impact
on the recognition and neutralization of the virus by the host cell. We present a comparative …

… The emergence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) variants
threatens efforts to contain the coronavirus disease 2019 (COVID-19) pandemic. Omicron (B…

… We herein describe recent advances in understanding SARS-CoV-2 pathobiology and …
SARS-CoV-2 viral entry, including neutralizing antibodies against the spike protein of SARS-CoV-…

… , LY-CoV555, is an intravenously administered neutralizing IgG monoclonal antibody directed
against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-… LY-CoV555 or a …

… (LYCoV555) as monotherapy and LY-CoV555 together with … steady in patients who received
LY-CoV555 for treating non-… contrasting spike protein on the SARSCoV-2 epitopes rather …

… Both E484A or Q493R greatly reduced binding for LY-CoV555, … RBD showed that although
LY-CoV555 has an angle of … of LY-CoV555, explaining the escape of B.1.1.529 from LY-…

… LY-CoV555 monotherapy or combination therapy with LY-CoV016 showed no difference
in viral load between LY-CoV555 … In contrast, combination therapy with LY-CoV555 and LY-…

… SARS-CoV-2 WA-1 strain. Significantly, as some antibodies currently in use like Lilly LY-CoV555 …
Surprisingly all four mAbs compete with LY-CoV555. Further, structural studies using …