Impact of New Variants on SAR-CoV-2 Infectivity and Neutralization: A Molecular Assessment of the Alterations in the Spike-Host Protein Interactions
… SARSCoV-2 and SARS-CoV… LY-CoV555 from its initial contact pose with the South African
RBD within 100 ns, confirming that the South African RBD could escape from mAb LY-CoV555…
RBD within 100 ns, confirming that the South African RBD could escape from mAb LY-CoV555…
Deconstructing SARS‐CoV‐2 neutralization: A modular molecular framework for computational design and comparison of antibodies and nanobodies targeting the …
V Tragni, I Mercurio, DP Paoletti… - Journal of Medical …, 2023 - Wiley Online Library
… This analysis revealed that only REGN10987 and LY-CoV555 derived nb (ie, the truncated
heavy chains of the cited ab FAB portions, see Figure 3) can target simultaneously the three …
heavy chains of the cited ab FAB portions, see Figure 3) can target simultaneously the three …
Broadly-neutralizing antibodies against emerging SARS-CoV-2 variants
… LY-CoV555 (clinical name bamlanivimab), currently used in the clinical setting in …
Another Class 2 antibody, MD65, has a binding pattern similar to LY-CoV555 but unlike LY-CoV555, …
Another Class 2 antibody, MD65, has a binding pattern similar to LY-CoV555 but unlike LY-CoV555, …
[HTML][HTML] Antibody resistance of SARS-CoV-2 variants B. 1.351 and B. 1.1. 7
… LY-CoV555 and S309, as well as for combination regimens of REGN10933 and REGN10987,
LY-CoV555 … LY-CoV555, alone or in combination with CB6, is no longer able to neutralize …
LY-CoV555 … LY-CoV555, alone or in combination with CB6, is no longer able to neutralize …
Potent neutralization of SARS-CoV-2 variants of concern by an antibody with an uncommon genetic signature and structural mode of spike recognition
… a considerable challenge to the clinical treatment of coronavirus disease (COVID-19). …
antibodies to SARS-CoV-2 is of utmost importance. Here, we report a panel of SARS-CoV-2 …
antibodies to SARS-CoV-2 is of utmost importance. Here, we report a panel of SARS-CoV-2 …
Discovery of ultrapotent broadly neutralizing antibodies from SARS-CoV-2 elite neutralizers
K Vanshylla, C Fan, M Wunsch, N Poopalasingam… - Cell host & …, 2022 - cell.com
… antibody response to SARS-CoV-2 with cross-reactivity to SARS-CoV-1. To uncover their
humoral response in detail, we performed single B cell analysis from 10 SARS-CoV-2 elite …
humoral response in detail, we performed single B cell analysis from 10 SARS-CoV-2 elite …
Ultrapotent antibodies against diverse and highly transmissible SARS-CoV-2 variants
L Wang, T Zhou, Y Zhang, ES Yang, CA Schramm… - Science, 2021 - science.org
… LY-CoV555 is a therapeutic antibody that binds RBD in both … contain mutations that confer
resistance to LY-CoV555 (14, 19, … binding profile of these antibodies to LY-CoV555. Although …
resistance to LY-CoV555 (14, 19, … binding profile of these antibodies to LY-CoV555. Although …
An engineered decoy receptor for SARS-CoV-2 broadly binds protein S sequence variants
… for the virus to escape. Notably, drugmaker Eli Lilly has a monoclonal monotherapy (LY-CoV555)
in advanced trials (NCT04427501) where the selection of resistant virus variants in …
in advanced trials (NCT04427501) where the selection of resistant virus variants in …
Therapeutic effect of CT-P59 against SARS-CoV-2 South African variant
… In contrast, LY-CoV555 showed preserved activity against the UK variant but activity … since
LY-CoV555 cannot bind to triple mutant protein (K417N/E484K/N501Y) of RBD in SARS-CoV-…
LY-CoV555 cannot bind to triple mutant protein (K417N/E484K/N501Y) of RBD in SARS-CoV-…
A broader neutralizing antibody against all the current VOCs and VOIs targets unique epitope of SARS-CoV-2 RBD
S Liu, Z Jia, J Nie, Z Liang, J Xie, L Wang, L Zhang… - Cell Discovery, 2022 - nature.com
… The neutralizing activity of three commercially available antibodies, LY-CoV555, REGN10987,
and REGN10933, against Omicron also decreased significantly. Surprisingly, one mAb, …
and REGN10933, against Omicron also decreased significantly. Surprisingly, one mAb, …