[HTML][HTML] Of mice and men: the coronavirus MHV and mouse models as a translational approach to understand SARS-CoV-2

RW Koerner, M Majjouti, MAA Alcazar, E Mahabir - Viruses, 2020 - mdpi.com
… and SARS-CoV could offer mechanistic insights into SARS-CoV-2. This review provides
a comprehensive review of MHV in mice and SARS-CoV… the detrimental course of SARS-CoV-2. …

Mouse models for the study of SARS-CoV-2 infection

AC Knight, SA Montgomery, CA Fletcher… - Comparative …, 2021 - ingentaconnect.com
… Virus was also detected in the brains of these mice, with the S protein of SARSCoV-2
identified in neurons, astrocytes, and microglia.Although differences in the expression of the …

[HTML][HTML] A mouse model of SARS-CoV-2 infection and pathogenesis

SH Sun, Q Chen, HJ Gu, G Yang, YX Wang… - Cell host & …, 2020 - cell.com
… Further characterization demonstrated that these humanized mice are highly susceptible
to SARS-CoV-2 infection via intranasal inoculation, and the viral kinetics and pathological …

SARS-CoV-2 causes lung infection without severe disease in human ACE2 knock-in mice

ES Winkler, RE Chen, F Alam, S Yildiz, JB Case… - Journal of …, 2022 - Am Soc Microbiol
… In this study, we evaluated SARS-CoV-2 infection of mice that express hACE2 under an
endogenous promoter in place of mACE2 (hACE2 knock-in [KI] mice). Human ACE2 was …

[HTML][HTML] Sex-specific SARS-CoV-2 mortality: among hormone-modulated ACE2 expression, risk of venous thromboembolism and hypovitaminosis D

S La Vignera, R Cannarella, RA Condorelli… - International journal of …, 2020 - mdpi.com
… partially protected these mice from lethal SARS. In addition, the … Finally, ovariectomy or
treatment of female mice with an … receptor signaling pathway in SARS-CoV infected mice [11]. In …

[PDF][PDF] Coronavirus COV-19/SARS-CoV-2 affects women less than men: clinical response to viral infection

P Conti, A Younes - J Biol Regul Homeost Agents, 2020 - researchgate.net
… , but probably also in dogs and mice, which can develop COVID-19. CoV-19 and its Spike
… How to reduce the likelihood of coronavirus-19 (CoV-19 or SARSCoV-2) infection and lung …

[HTML][HTML] Impact of age and sex on neuroinflammation following SARS-CoV-2 infection in a murine model

VD Krishna, A Chang, H Korthas, SR Var… - Frontiers in …, 2024 - frontiersin.org
… Wild-type C57BL/6J mice were intranasally inoculated with SARS-CoV-2 lineage B.1.351,
a … from SARS-CoV-2 infected mice, we assessed the impact of age and sex on SARS-CoV-2 …

[HTML][HTML] Emerging SARS-CoV-2 variants expand species tropism to murines

H Shuai, JFW Chan, TTT Yuen, C Yoon, JC Hu… - …, 2021 - thelancet.com
… carrying variants but not WT SARS-CoV-2 can infect wildtype mice. High viral genome copies
… Our results demonstrate that while wildtype mice are not permissive to WT SARS-CoV-2, B.…

Sex-based differences in susceptibility to severe acute respiratory syndrome coronavirus infection

R Channappanavar, C Fett, M Mack… - The Journal of …, 2017 - journals.aai.org
… 2002–2003 SARSmice of different age groups with SARS-CoV and analyzed their
susceptibility to the infection. Our results showed that male mice were more susceptible to …

[HTML][HTML] SARS-CoV-2 viral entry proteins in hyperandrogenemic female mice: implications for women with PCOS and COVID-19

AM Huffman, S Rezq, J Basnet… - International journal of …, 2021 - mdpi.com
… We hypothesize that elevated androgens in PCOS regulate SARS-CoV-2 entry proteins
in multiple tissues increasing the risk for this population. Female mice were treated with …