Drugs against SARSCoV‐2: What do we know about their mode of action?

C Valle, B Martin, F Touret, A Shannon… - Reviews in medical …, 2020 - Wiley Online Library
SARS-CoV-2 life cycle and potential mechanisms of action of currently evaluated therapeutics.
SARS-CoV… presumed mechanisms of action (MoA) of the main SARS-CoV-2 replication …

[HTML][HTML] Prospective mode of action of Ivermectin: SARS-CoV-2

VM Patil, S Verma, N Masand - European Journal of Medicinal Chemistry …, 2022 - Elsevier
SARS-CoV-2. Present manuscript attempts to provide an overview of the detailed mechanism
of action … The knowledge of binding interaction of IVM and SARS-CoV-2 targets will give …

A systematic review of experimental evidence for antiviral effects of ivermectin and an in silico analysis of ivermectin's possible mode of action against SARSCoV‐2

RT Kinobe, L Owens - Fundamental & clinical pharmacology, 2021 - Wiley Online Library
… At the time of writing, only one published, peer-reviewed paper [28] on the in vitro effect of
ivermectin against SARS-CoV-2 exists, so this review contains in vitro and in vivo studies and …

Structural basis and mode of action for two broadly neutralizing antibodies against SARS-CoV-2 emerging variants of concern

W Li, Y Chen, J Prévost, I Ullah, M Lu, SY Gong… - Cell reports, 2022 - cell.com
… for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can transmit more
… Here, we elucidate the structural basis and mode of action for two potent SARS-CoV-2 spike …

Anti-SARS-CoV-2 potential of artemisinins in vitro

R Cao, H Hu, Y Li, X Wang, M Xu, J Liu… - ACS Infectious …, 2020 - ACS Publications
… (14) In this study, we systematically evaluated the antiviral potential of artemisinins against
SARS-CoV-2 in vitro and discovered that artesunate could inhibit SARS-CoV-2 replication in …

… algae-derived bioactive metabolites as antiviral agents: Evidence, mode of action, and scope for further expansion; a comprehensive review in light of the SARS-CoV …

B Pradhan, R Nayak, S Patra, PP Bhuyan, SR Dash… - Antioxidants, 2022 - mdpi.com
COVID-19—a severe acute respiratory syndrome disease caused by coronavirus 2 (SARS-CoV-2)—has
recently attracted global attention, due to its devastating impact, to the point of …

A review on possible modes of action of chloroquine/hydroxychloroquine: repurposing against SAR-CoV-2 (COVID-19) pandemic

S Tripathy, B Dassarma, S Roy, H Chabalala… - International journal of …, 2020 - Elsevier
… , here we highlight the possible modes of action of CQ/HCQ that … HCQ, for the treatment of
SARS-CoV-2 infection could be a … azithromycin in the treatment of SARS CoV-2 infection 500 3 …

[HTML][HTML] Insights into antiviral mechanisms of remdesivir, lopinavir/ritonavir and chloroquine/hydroxychloroquine affecting the new SARS-CoV-2

K Uzunova, E Filipova, V Pavlova, T Vekov - Biomedicine & …, 2020 - Elsevier
… in week 2 is apparently unrelated to uncontrolled SARS coronavirus replication but may be
related to immunopathological damage [92]. Another study reveals that the presence of viral …

The mechanisms of action of ivermectin against SARS-CoV-2—an extensive review

AK Zaidi, P Dehgani-Mobaraki - The Journal of antibiotics, 2022 - nature.com
… discuss the probable mechanisms of action of ivermectin against SARS-CoV-2 by summarizing
… interactions between ivermectin, host cell, and SARS-CoV-2 in COVID-19 pathogenesis …

Kill or corrupt: Mechanisms of action and drug-resistance of nucleotide analogues against SARS-CoV-2

A Shannon, B Canard - Antiviral Research, 2023 - Elsevier
… Here, we describe the mechanism of action of four promising anti-COVID-19 NAs;
remdesivir, molnupiravir, favipiravir and bemnifosbuvir. Their distinct mechanisms of action best …