Neutralizing and protective human monoclonal antibodies recognizing the N-terminal domain of the SARS-CoV-2 spike protein

N Suryadevara, S Shrihari, P Gilchuk, LA VanBlargan… - Cell, 2021 - cell.com
monoclonal antibodies (mAbs) neutralizing SARS-CoV-2 … (NTD) of S protein from
SARS-CoV-2 convalescent donors and … of authentic SARS-CoV-2 and recombinant VSV/SARS-CoV-2 …

Receptor-binding domain-specific human neutralizing monoclonal antibodies against SARS-CoV and SARS-CoV-2

F Yu, R Xiang, X Deng, L Wang, Z Yu, S Tian… - … and Targeted Therapy, 2020 - nature.com
… –510 of the SARS-CoV S protein. Affinity measurements showed an affinity Kd of 34 nM
between monoclonal antibodies (mAbs) and soluble S 590 (residues 1–590 of the SARS-CoV S …

Human-IgG-neutralizing monoclonal antibodies block the SARS-CoV-2 infection

J Wan, S Xing, L Ding, Y Wang, C Gu, Y Wu, B Rong… - Cell reports, 2020 - cell.com
antibodies have therapeutic potential. We have purified more than 1,000 memory B cells
specific to SARS-CoV-2 … Among these, 178 antibodies test positive for antigen binding, and the …

Human monoclonal antibodies block the binding of SARS-CoV-2 spike protein to angiotensin converting enzyme 2 receptor

X Chen, R Li, Z Pan, C Qian, Y Yang, R You… - Cellular & molecular …, 2020 - nature.com
… Consistently, we also found that SARS-CoV-2 RBD-specific IgG antibodies were present in
… whether RBD-specific antibodies in patient serum can block the binding of SARS-CoV-2 RBD …

The SARS-CoV-2 monoclonal antibody combination, AZD7442, is protective in nonhuman primates and has an extended half-life in humans

YM Loo, PM McTamney, RH Arends… - Science translational …, 2022 - science.org
Despite the success of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …
remaining at risk of coronavirus disease 2019 (COVID-19). Monoclonal antibodies (mAbs) …

Reduced neutralization of SARS-CoV-2 Omicron variant by vaccine sera and monoclonal antibodies

A Wilhelm, M Widera, K Grikscheit, T Toptan, B Schenk… - MedRxiv, 2021 - medrxiv.org
… of vaccinations and monoclonal antibodies. Our in vitro findings using authentic SARS-CoV-2 …
Since SARS-CoV-2 Omicron was resistant to casirivimab and imdevimab, genotyping of …

A monoclonal antibody that neutralizes SARS-CoV-2 variants, SARS-CoV, and other sarbecoviruses

P Wang, RG Casner, MS Nair, J Yu, Y Guo… - Emerging microbes & …, 2022 - Taylor & Francis
… activity against SARS-CoV. We solved the cryo-EM structure of 2–36 in complex with
SARS-CoV-2 or SARS-CoV spike, … Antibody 2–36 neutralized not only all current circulating …

Generation of SARS-CoV-2 escape mutations by monoclonal antibody therapy

M Ragonnet-Cronin, R Nutalai, J Huo… - Nature …, 2023 - nature.com
… treated with neutralising monoclonal antibodies (mAbs)… antibodies targeting relatively
conserved regions, individually eg sotrovimab. Unprecedented genomic surveillance of SARS-CoV

Realizing the potential of anti–SARS-CoV-2 monoclonal antibodies for COVID-19 management

JZ Li, RT Gandhi - Jama, 2022 - jamanetwork.com
… What are the current roles for anti–SARS-CoV-2 monoclonal antibodies and how might they
be used in the future? At this time, anti–SARS-CoV-2 monoclonal antibodies are authorized …

Structural insights into the cross-neutralization of SARS-CoV and SARS-CoV-2 by the human monoclonal antibody 47D11

J Fedry, DL Hurdiss, C Wang, W Li, G Obal, I Drulyte… - Science …, 2021 - science.org
… The emergence of SARS-CoV-2 antibody escape mutations highlights the urgent need for …
monoclonal antibody, 47D11, capable of cross-neutralizing SARS-CoV-2 and SARS-CoV and …